High-Throughput Docking and Molecular Dynamics Simulations towards the Identification of Potential Inhibitors against Human Coagulation Factor XIIa

High-Throughput Docking and Molecular Dynamics Simulations towards the Identification of Potential Inhibitors against Human Coagulation Factor XIIa
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高通量对接和分子动力学模拟识别人类凝血因子 XIIa 的潜在抑制剂

DOI:
10.1155/2020/2852051
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发表时间:
2020-05
影响因子:
--
通讯作者:
Lihu Gong
Lihu Gong
中科院分区:
工程技术4区
文献类型:
--
作者:
Dongfang Xu;Guangpu Xue;Bangya Peng;Zanjie Feng;Hongling Lu;Lihu Gong

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人凝血因子XIIa(FXIIa)是一种胰蛋白酶样丝氨酸蛋白酶,参与病理性血栓形成。作为设计安全抗凝剂的潜在靶点,FXIIa近年来受到了极大的关注。在本研究中,
Human coagulation factor XIIa (FXIIa) is a trypsin-like serine protease that is involved in pathologic thrombosis. As a potential target for designing safe anticoagulants, FXIIa has received a great deal of interest in recent years. In the present study,
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