SIMULTANEOUS INTEGRATED BOOST USING INTENSITY-MODULATED RADIOTHERAPY COMPARED WITH CONVENTIONAL RADIOTHERAPY IN PATIENTS TREATED WITH CONCURRENT CARBOPLATIN AND 5-FLUOROURACIL FOR LOCALLY ADVANCED OROPHARYNGEAL CARCINOMA
SIMULTANEOUS INTEGRATED BOOST USING INTENSITY-MODULATED RADIOTHERAPY COMPARED WITH CONVENTIONAL RADIOTHERAPY IN PATIENTS TREATED WITH CONCURRENT CARBOPLATIN AND 5-FLUOROURACIL FOR LOCALLY ADVANCED OROPHARYNGEAL CARCINOMA
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DOI：
10.1016/j.ijrobp.2010.10.061
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发表时间：
2012-02-01
影响因子：
7
通讯作者：
Phuc Felix Nguyen-Tan
中科院分区：
文献类型：
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作者：
Clavel, Sebastien;Nguyen, David H. A.;Phuc Felix Nguyen-Tan
目的：比较，在一项回顾性研究中，毒性和疗效的同时整合加强使用调强放疗（IMRT）与常规放疗（CRT）的患者与伴随卡铂和5-氟尿嘧啶治疗局部晚期口咽cancer.Methods和材料：2000年1月至2007年12月，249例患者进行了明确的放化疗。100例患者接受了70戈伊的调强放疗，分33次进行，149例患者接受了70戈伊的CRT，分35次进行。使用Kaplan-Meier方法估计总生存率、无病生存率和局部控制率。IMRT和CRT的3年局部控制率、无病生存率和总生存率分别为95.1%和84.4%（p = 0.005），85.3%和69.3%（p = 0.001），92.1%和75.2%（p < 0.001）。考克斯多变量分析也观察到放疗方案对结局的益处。调强放疗与6，12，24，和36 months.Conclusions急性皮炎和口腔干燥症较少，本研究表明，同时使用调强放射治疗的综合加强与良好的局部区域控制和生存率，口腔干燥症和急性皮炎比CRT时，同时给予化疗。(C)2012 Elsevier Inc.
Purpose: To compare, in a retrospective study, the toxicity and efficacy of simultaneous integrated boost using intensity-modulated radiotherapy (IMRT) vs. conventional radiotherapy (CRT) in patients treated with concomitant carboplatin and 5-fluorouracil for locally advanced oropharyngeal cancer.Methods and Materials: Between January 2000 and December 2007, 249 patients were treated with definitive chemoradiation. One hundred patients had 70 Gy in 33 fractions using IMRT, and 149 received CRT at 70 Gy in 35 fractions. Overall survival, disease-free survival, and locoregional control were estimated using the Kaplan-Meier method.Results: Median follow-up was 42 months. Three-year actuarial rates for locoregional control, disease-free survival, and overall survival were 95.1% vs. 84.4% (p = 0.005), 85.3% vs. 69.3% (p = 0.001), and 92.1% vs. 75.2% (p < 0.001) for IMRT and CRT, respectively. The benefit of the radiotherapy regimen on outcomes was also observed with a Cox multivariate analysis. Intensity-modulated radiotherapy was associated with less acute dermatitis and less xerostomia at 6, 12, 24, and 36 months.Conclusions: This study suggests that simultaneous integrated boost using IMRT is associated with favorable locoregional control and survival rates with less xerostomia and acute dermatitis than CRT when both are given concurrently with chemotherapy. (C) 2012 Elsevier Inc.