Adult community-acquired pneumonia caused by macrolide resistant Mycoplasma pneumoniae
Adult community-acquired pneumonia caused by macrolide resistant Mycoplasma pneumoniae
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DOI：
10.1111/j.1440-1843.2009.01619.x
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发表时间：
2009-11-01
期刊：
影响因子：
6.9
通讯作者：
Ariyoshi, Koya
中科院分区：
文献类型：
--
作者：
Isozumi, Rie;Yoshimine, Hiroyuki;Ariyoshi, Koya
1例28岁女性社区获得性肺炎患者接受舒巴坦/氨苄西林和克拉霉素治疗，但4天后未见任何改善。抗生素方案改为帕珠沙星，临床改善迅速。肺炎支原体被鉴定为病原体，在该分离株中发现了23S rRNA结构域V区2063位的腺嘌呤(A)到鸟嘌呤(G)突变。该菌株对包括克拉霉素在内的大环内酯类抗生素的最低抑菌浓度有较大提高。
A 28-year-old woman with community-acquired pneumonia was treated with sulbactam/ampicillin and clarithromycin, but failed to show any improvement after 4 days. The antibiotic regimen was changed to pazufloxacin and rapid clinical improvement was seen. Mycoplasma pneumoniae was identified as the causative agent, and adenine (A) to guanine (G) mutation at position 2063 in domain V of the 23S rRNA was noted in the isolate. The minimum inhibitory concentration of macrolide antibiotics, including clarithromycin, of this isolate was greatly elevated.