Growth Hormone Induces Recurrence of Infantile Hemangiomas After Apparent Involution: Evidence of Growth Hormone Receptors in Infantile Hemangioma.
Growth Hormone Induces Recurrence of Infantile Hemangiomas After Apparent Involution: Evidence of Growth Hormone Receptors in Infantile Hemangioma.
复制标题
生长激素在明显复旧后诱导婴儿血管瘤复发：婴儿血管瘤中生长激素受体的证据。
DOI：
10.1111/pde.12530
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发表时间：
2015
影响因子：
1.5
通讯作者：
Wu,JuneK
中科院分区：
文献类型：
--
作者：
Munabi,NaikhobaCO;Tan,QianKun;Garzon,MariaC;Behr,GeraldG;Shawber,CarrieJ;Wu,JuneK
婴儿血管瘤（IH）是婴儿期最常见的良性肿瘤，其特征在于在生命的最初几个月的早期增殖到在儿童期的最终退化的自然史，通常具有残留的纤维脂肪组织。一旦达到退化，IH通常不会复发。我们提出了两个案件的外源性生长激素治疗导致复发的IH在儿童后期，支持放射学，免疫组化，在体外和体内的证据。
Infantile hemangiomas (IHs) are the most common benign tumor of infancy, characterized by a natural history of early proliferation in the first months of life to eventual involution during childhood, often with residual fibrofatty tissue. Once involution has been achieved, IHs do not typically recur. We present two cases of exogenous growth hormone therapy resulting in the recurrence of IHs in late childhood, supported by radiological, immunohistochemical, in vitro, and in vivo evidence.