Chaotic hemodynamic during oscillated blood flow.
Chaotic hemodynamic during oscillated blood flow.
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振荡血流期间血流动力学混乱。
DOI：
10.1111/j.1525-1594.1994.tb03391.x
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发表时间：
1994
影响因子：
2.4
通讯作者：
H. Hashimoto
中科院分区：
文献类型：
--
作者：
T. Yambe;S. Nitta;T. Sonobe;S. Naganuma;Y. Kakinuma;S. Kobayashi;Motonao Tanaka;T. Fukuju;M. Miura;Naoshi Sato;Hitoshi Mohri;Satoshi Koide;H. Takeda;M. Yoshizawa;Takeshi Kasai;H. Hashimoto
我们的团队为人工心脏系统开发了一种振动流泵（VFP），可以产生振荡血流（10-50 Hz/min）。然而，该泵的流动模式不同于自然心脏的流动模式;因此，分析这种振荡的血液流动对循环调节系统的影响是重要的。为了将高频振荡血流作为一个整体（未分解）进行血液动力学分析，采用了非线性数学方法。在动物实验中，使用成年山羊将VFP植入左心房之间。植入后，夹闭升主动脉，用VFP建立完整的左心循环。利用非线性数学方法，将动脉血压波形嵌入到四维相空间，并投影到三维相空间。李雅普诺夫数值方法被用来作为一个辅助的图形分析的状态空间。吸引子的相图显示出高维复杂结构，表明自然循环过程中存在确定性混沌。然而，在振荡血流的血流动力学的相图显示一个单一的圆圈带和一个禁区，类似于一个极限环吸引子，这表明一个低维的动力学系统。正的李雅普诺夫指数在振荡的血液流动表明低维混沌动力学的存在。这些结果表明，血液流动振荡期间的循环调节系统可能是一种低维的稳态混沌状态;因此，当出现意外的外部刺激时，必须仔细调节血液动力学参数。
A vibrating flow pump (VFP), which can generate oscillated blood flow (10-50 Hz/min), has been developed by our team for the artificial heart system. However, the flow pattern of this pump was different from that of the natural heart; therefore, it is important to analyze the effect of this oscillated blood flow on the circulatory regulatory system. To analyze the hemodynamics of high frequency oscillated blood flow as an entity, (not decomposed), nonlinear mathematical techniques were utilized. VFPs were implanted between the left atrium in animal experiments using adult goats. After the implantation procedure, the ascending aorta was clamped to constitute the complete left heart circulation with VFP. Using a nonlinear mathematical technique, an arterial blood pressure waveform was embedded into four-dimensional phase space and projected into three-dimensional phase space. The Lyapunov numerical method was used as an adjunct to graphic analysis of the state space. Phase portrait of the attractor showed a high dimension complex structure, suggesting deterministic chaos during natural circulation. However, phase portrait of the hemodynamics during oscillated blood flow showed a single circle with banding and a forbidden zone, similar to a limit-cycle attractor, suggesting a lower dimensional dynamic system. Positive Lyapunov exponent during oscillated blood flow suggests the existence of lower dimensional chaotic dynamics. These results suggest that the circulatory regulatory system during oscillated blood flow may be a lower dimensional homeochaotic state; thus, hemodynamic parameters must be carefully regulated when unexpected external stimuli are present.