Obesity and related consequences to ageing
Obesity and related consequences to ageing
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DOI：
10.1007/s11357-016-9884-3
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发表时间：
2016-02-01
期刊：
影响因子：
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通讯作者：
Kozak, Leslie. P.
中科院分区：
文献类型：
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作者：
Jura, Magdalena;Kozak, Leslie. P.
肥胖已成为一个主要的公共卫生问题。鉴于目前预期寿命的增加，肥胖症在老年群体中的流行率也在稳步上升。预期寿命的增加往往伴随着老年人易患与肥胖有关的慢性疾病的时间增加。肥胖和衰老都是导致严重健康问题和增加疾病和死亡风险的条件。衰老与腹部肥胖的增加有关，腹部肥胖是胰岛素抵抗和代谢综合征的主要原因。因此，老年人肥胖是一个严重的问题，了解衰老和与年龄有关的疾病的关键机制已成为一个必要的问题。在这里，我们的目的是确定与肥胖和衰老相关的潜在机制的相似性。我们汇集了证据表明，与年龄相关的身体脂肪分布和代谢变化可能是恶性循环的关键因素，可以加速衰老过程和与年龄相关的疾病的发生。
Obesity has become a major public health problem. Given the current increase in life expectancy, the prevalence of obesity also raises steadily among older age groups. The increase in life expectancy is often accompanied with additional years of susceptibility to chronic ill health associated with obesity in the elderly. Both obesity and ageing are conditions leading to serious health problems and increased risk for disease and death. Ageing is associated with an increase in abdominal obesity, a major contributor to insulin resistance and the metabolic syndrome. Obesity in the elderly is thus a serious concern and comprehension of the key mechanisms of ageing and age-related diseases has become a necessary matter. Here, we aimed to identify similarities underlying mechanisms related to both obesity and ageing. We bring together evidence that age-related changes in body fat distribution and metabolism might be key factors of a vicious cycle that can accelerate the ageing process and onset of age-related diseases.