Repeated antigen exposure is necessary for the differentiation, but not the initial proliferation, of naive CD4+ T cells
Repeated antigen exposure is necessary for the differentiation, but not the initial proliferation, of naive CD4+ T cells
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DOI：
10.4049/jimmunol.168.4.1723
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发表时间：
2002-02-15
影响因子：
4.4
通讯作者：
Guerder, S
中科院分区：
文献类型：
--
作者：
Bajénoff, M;Wurtz, O;Guerder, S
体内调节CD4(+)T细胞反应的机制仍然知之甚少。我们在这里表明，最初的抗原刺激诱导了CD4(+)T细胞的增殖程序，在不需要随后的抗原或细胞因子的情况下，该程序可以发展至少七个分裂周期。此后，增殖停止，但可以通过新的抗原刺激重新启动。然而，这种最初的抗原刺激不足以诱导初始的CD4(+)T细胞分化为效应Th1细胞，这需要与载银的APC多次接触。因此，反复暴露于Ag和极化细胞因子似乎对产生干扰素的细胞的分化至关重要。因此，AG和细胞因子的可获得性极大地限制了CD4(+)T细胞向产生干扰素-γ的细胞的分化，而不是最初的增殖。
The mechanisms that regulate CD4(+) T cells responses in vivo are still poorly understood. We show here that initial Ag stimulation induces in CD4(+) T cells a program of proliferation that can develop, for at least seven cycles of division, in the absence of subsequent Ag or cytokine requirement. Thereafter, proliferation stops but can be reinitiated by novel Ag stimulation. This initial Ag stimulation does not however suffice to induce the differentiation of naive CD4(+) T cells into effector Th1 cells which requires multiple contacts with Ag-loaded APC. Thus, recurrent exposure to both Ag and polarizing cytokines appears to be essential for the differentiation of IFN-gamma-producing cells. Ag and cytokine availability therefore greatly limits the differentiation, but not the initial proliferation, of CD4(+) T cells into IFN-gamma-producing cells.