Devazepide alters meal patterns in lean, but not obese, male Zucker rats.
Devazepide alters meal patterns in lean, but not obese, male Zucker rats.
复制标题
地维西吡改变瘦雄性 Zucker 大鼠的膳食模式，但不会改变肥胖雄性 Zucker 大鼠的膳食模式。
DOI：
10.1016/0031-9384(94)90340-9
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发表时间：
1994
影响因子：
2.9
通讯作者：
Greenberg,D
中科院分区：
文献类型：
--
作者：
Strohmayer,AJ;Greenberg,D
在用A型胆囊收缩素（CCKA）受体拮抗剂、地瓦卓（750 μg/kg，IP，1330 h）或溶剂处理后，记录6只瘦型和8只肥胖型成年雄性Zucker大鼠10.5 h的进食模式。在瘦大鼠中，devazepide显著增加总食物摄入量11%，平均膳食量35%，进餐时间49%。Devazepide也显著减少了18%的平均用餐次数，尽管这是一个较小的影响。在肥胖大鼠中，德瓦卓派没有这些作用。Devazepide治疗改变了瘦大鼠的饮食模式，使其与肥胖大鼠相似。这些结果表明，内源性CCK在精瘦的雄性Zucker大鼠中具有饱腹感作用，但在肥胖的雄性Zucker大鼠中不具有饱腹感作用，这是首次证明肥胖Zucker大鼠中生理饱腹感信号的丧失。这种缺陷可能是由于：1）内源性CCK释放减少，2）CCK合成速率降低，或3）产生异常形式的CCK。
Meal patterns were recorded for 10.5 h in six lean and eight obese adult male Zucker rats after treatment with the cholecystokinin type A (CCKA) receptor antagonist, devazepide (750 μg/kg, IP, at 1330 h) or vehicle. In lean rats, devazepide significantly increased total food intake by 11%, average meal size by 35%, and meal duration by 49%. Devazepide also significantly decreased the average number of meals by 18%, although this was a smaller effect. Devazepide had none of these effects in obese rats. Devazepide treatment altered the meal pattern of lean rats so that it was similar to that of obese rats. These results demonstrate that endogenous CCK has a satiating effect in lean, but not in obese, male Zucker rats, which is the first demonstration of a loss of a physiological satiety signal in the obese Zucker rat. This defect could be due to: 1) a decrease in the release of endogenous CCK, 2) a decrease in the rate of CCK synthesis, or 3) the production of an abnormal form of CCK.