Advances in Brief Suppression of Human Bladder Cancer Growth by Increased Expression of C-CAM 1 Gene in an Orthotopic Model '
Advances in Brief Suppression of Human Bladder Cancer Growth by Increased Expression of C-CAM 1 Gene in an Orthotopic Model '
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发表时间：
2006
期刊：
影响因子：
24.2
通讯作者：
David;I. Kleinerman;Colin;P. N. Dinney;Wei-Wei-Wei;Zhang;Sue-Hwa;Lin;Nguyen;T. Van;Jer-Tsong;Hsieh
中科院分区：
文献类型：
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作者：
David;I. Kleinerman;Colin;P. N. Dinney;Wei-Wei-Wei;Zhang;Sue-Hwa;Lin;Nguyen;T. Van;Jer-Tsong;Hsieh
犯罪和/或吸毒方式决定了器官的发育和正常生理功能（6，7）。此外，最近的数据表明，来自肿瘤周围微环境的基质成分不仅在改变肿瘤细胞的生物学行为方面，而且在决定肿瘤细胞的Meta模式方面也可能发挥关键作用（8 - 10）。通常，这种相互作用似乎是器官特异性的（11）。因此，要检查任何药物对肿瘤行为的影响，关键是要考虑周围微环境的潜在影响。在本研究中，我们决定使用原位膀胱模型（12），使用两种性别的宿主来评估C-CAM 1对人膀胱癌进展的肿瘤抑制作用。
crime and/or juxacrine fashion dictates the development and the nor mal physiological function of an organ (6, 7). In addition, recent data show that the stromal component from tumor-surrounding microen vironments may also play a crucial role not only in changing the biological behavior of tumor cells but also in determining the meta static pattern of tumor cells (8—10). Very often, this interaction appears to be organ specific (1 1). Therefore, to examine the effect of any agents on tumor behavior, it is crucial to consider the potential influence from the surrounding microenvironment. In this study, we decided to use an orthotopic bladder model (12) using hosts of both genders to assess the tumor suppressive effect of C-CAM 1 on human bladder cancer progression.