Does the Severity of Obesity Influence Bone Mineral Density Values in Premenopausal Women?
Does the Severity of Obesity Influence Bone Mineral Density Values in Premenopausal Women?
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DOI：
10.1016/j.jocd.2019.04.006
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发表时间：
2021-04-16
影响因子：
2.5
通讯作者：
El Hage, Rawad
中科院分区：
文献类型：
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作者：
Hammoud, Emneh;Toumi, Hechmi;El Hage, Rawad
本研究的目的是比较骨矿物质含量（BMC），骨矿物质密度（BMD），髋骨强度的几何指数之间的3组成年肥胖绝经前妇女（严重肥胖，病态肥胖，超病态肥胖）。该研究包括65名体重指数（BMI）> 35 kg/m2的年轻成年绝经前妇女。使用BMI的国际截止值将他们分为3组。身体成分和骨变量进行了测量DXA。完成全身（WB）、腰椎、全髋（TH）和股骨颈（FN）的DXA测量。通过DXA计算FN强度的几何指标（横截面积、横截面惯性矩[CSMI]、截面模量[Z]、强度指数[SI]和屈曲比）。结果显示，3组间年龄、身高差异无统计学意义。与严重和病态肥胖妇女相比，超级病态肥胖妇女的WB BMC值更高。WB BMD、L1-L4 BMD、全髋BMD、FN BMD、横截面积、CSMI、Z和屈曲比值在3组之间无显著差异。与病态和严重肥胖女性相比，超级病态肥胖女性的SI值较低。在整个人群中（n = 65），体重，BMI，瘦体重，脂肪量和躯干脂肪量呈正相关，WB BMC和SI呈负相关。体重和瘦体重与WB BMD和CSMI呈正相关。我们的研究结果表明，肥胖的严重程度并不影响绝经前妇女的BMD值。
The aim of this study was to compare bone mineral content (BMC), bone mineral density (BMD), and geometric indices of hip bone strength among 3 groups of adult obese premenopausal women (severely obese, morbidly obese, and super morbidly obese). This study included 65 young adult premenopausal women whose body mass index (BMI) > 35 kg/m2. They were divided into 3 groups using international cut-offs for BMI. Body composition and bone variables were measured by DXA. DXA measurements were completed for the whole body (WB), lumbar spine, total hip (TH), and femoral neck (FN). Geometric indices of FN strength (cross-sectional area, cross-sectional moment of inertia [CSMI], section modulus [Z], strength index [SI], and buckling ratio) were calculated by DXA. Results showed that age and height were not significantly different among the 3 groups. WB BMC values were higher in super morbidly obese women compared to severely and morbidly obese women. WB BMD, L1-L4 BMD, total hip BMD, FN BMD, cross-sectional area, CSMI, Z, and buckling ratio values were not significantly different among the 3 groups. SI values were lower in super morbidly obese compared to morbidly and severely obese women. In the whole population (n = 65), body weight, BMI, lean mass, fat mass, and trunk fat mass were positively correlated to WB BMC and negatively correlated to SI. Weight and lean mass were positively correlated to WB BMD and CSMI. Our findings suggest that the severity of obesity does not influence BMD values in premenopausal women.