Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder
Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder
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DOI：
10.1016/j.biopsych.2004.10.004
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发表时间：
2005-01-15
影响因子：
10.6
通讯作者：
Sachsse, U
中科院分区：
文献类型：
--
作者：
Irle, E;Lange, C;Sachsse, U
背景：越来越多的证据表明边缘性人格障碍（BPD）和创伤后应激障碍（PTSD）与海马体积过小有关。精神病症状在这两种疾病中都很常见。已知精神病谱系障碍与颞顶皮质异常有关。方法：使用结构磁共振成像 (3D-MRI)，将 30 名曾遭受过严重童年性虐待和身体虐待的 BPD 年轻女性以及 25 名健康对照受试者的顶叶皮质和海马体积关联起来。结果：与对照受试者相比，BPD 受试者的右顶叶皮质 (-11%) 和海马 (17%) 体积明显较小。与对照组相比，边缘受试者的顶叶皮层表现出明显更强的左向不对称性。边缘受试者中较强的精神病症状和精神分裂人格特征与左向不对称性的减少显着相关。更强的创伤相关临床症状和神经心理缺陷与较小的海马体积显着相关。结论：我们的结果与之前 BPD 和 PTSD 患者海马体积较小的研究结果一致。边缘性人格障碍患者右顶叶皮层尺寸减小可能反映了右半球的神经发育缺陷。
Background: Evidence is accumulating that suggests borderline personality disorder(BPD) and posttraumatic stress disorder(PTSD) are related to small hippocampal size. Psychotic symptoms are frequent in both disorders. Psychotic spectrum disorders are known to be related to abnormalities of temporoparietal cortices.Methods: Using structural magnetic resonance imaging (3D-MRI), parietal cortex and hippocampal volumes were associated in 30 young women with BPD who had been exposed to severe childhood sexual and physical abuse and in 25 healthy control subjects.Results: Compared with control subjects, BPD subjects had significantly smaller right parietal cortex (-11%) and hippocampal (17%) volumes. The parietal cortex of borderline subjects showed a significantly stronger leftward asymmetry when compared with control subjects. Stronger psychotic symptoms and schizoid personality traits in borderline subjects were significantly related to reduced leftward asymmetry. Stronger trauma-related clinical symptoms and neuropsychologic deficits were significantly related to smaller hippocampal size.Conclusions: Our results are consistent with previous findings of small hippocampal size in BPD and PTSD. Reduced right parietal cortex size in individuals with BPD may reflect a neurodevelopmental deficit of the right hemisphere.