A multifunctional nanoplatform for improving microwave hyperthermia by a combination therapy of vessel disruptive agent and immune modulator
A multifunctional nanoplatform for improving microwave hyperthermia by a combination therapy of vessel disruptive agent and immune modulator
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DOI：
10.1016/j.colsurfb.2022.112616
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Xianwei Meng
中科院分区：
文献类型：
--
作者：
Zhiheng Zeng;Xiaohan Sun;Zhongbing Huang;Changhui Fu;Jun Ren;Meng Niu;Longfei Tan;Xiangling Ren;Qiong Wu;Xianwei Meng
Microwave (MW) hyperthermia is one of the safest and most efficient minimally invasive tumor treatment methods, it is restricted by the bottlenecks of the heat sink effect and ineffective immune activation. Herein, a multifunctional nano platform with the load of nano immune modulator bimetallic metal-organic framework (BM), tumor vessel destructive agent and prodrug for gas production is developed for improving MW hyperthermia. Specifically, the combretastatin A4 phosphate (CA4P) was a vessel destructive agent to reduce MW heat loss by destructing the tumor blood vessel. Moreover, the as designed BM can scavenge the endogenic reactive oxygen species, which is conducive to hydrogen sulfide gas (H 2 S) that produced by bismuth sulfide (Bi 2 S 3 ) to activate immune cells. Our in vivo experimental results demonstrate the destruction of tumor blood vessels coupled with the activated immune system results in the remarkable antitumor effect. This study provides an efficient strategy to improve MW hyperthermia by a combination of vasculature-targeting therapy with systemic immunity. • A bi-metal organic frameworks nanoplatform with vessel disruptive agent & immune modulator was prepared. • It was used in vascular-immunotherapy and MW hyperthermia. • Tumor at 14th day was disappear.
