Nongenomically initiated steroid actions
Nongenomically initiated steroid actions
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DOI：
10.1046/j.1365-2362.2000.0300s3051.x
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发表时间：
2000-12-01
影响因子：
5.5
通讯作者：
Wehling, M
中科院分区：
文献类型：
--
作者：
Falkenstein, E;Wehling, M
类固醇激素作用的经典理论包括与细胞内受体结合，然后调节转录和翻译事件。这些繁琐的模型解释了这些基因组类固醇效应的特征潜伏期。在过去的二十年里，越来越多的证据表明类固醇的快速非基因组效应与传统模型不相容。这些替代类固醇效应已被描述为所有类别的类固醇和具有不同作用机制的多种物种和组织。
The classical theory of steroid hormone action comprises binding to an intracellular receptor followed by modulation of transcriptional and translational events. These cumbersome model explains the characteristic latency of these genomic steroid effects. Over the past two decades, increasing evidence for rapid nongenomic effects of steroids, incompatible with the traditional model, has accumulated. These alternative steroid effects have been described for all classes of steroids and a multitude of species and tissues with differ ent mechanisms of action.