Chemical constituents from the aerial parts of Melandrium firmum
Chemical constituents from the aerial parts of Melandrium firmum
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DOI：
10.1007/s12272-014-0545-8
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发表时间：
2015-01
影响因子：
6.7
通讯作者：
Changhao Zhang;Jie Luo;Tian Li;Yong Cui;Mei Jin;Dalei Yao;M. Zheng;Z. Lin;J. Cui;Gao Li-Gao
中科院分区：
文献类型：
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作者：
Changhao Zhang;Jie Luo;Tian Li;Yong Cui;Mei Jin;Dalei Yao;M. Zheng;Z. Lin;J. Cui;Gao Li-Gao
从硬叶密蒙花（MelandriumfirmumRohrbach）地上部分分得两个新的蒽醌类化合物，即melrubiellinC（1）和melrubiellinD（2），以及八个已知化合物（3-10）。利用1D和2D NMR（COSY、HMQC、HMBC和NOESY）实验对这些化合物的结构进行了鉴定。测试所有分离的化合物对NCI-H460、Hep G2、MKN-28和A-549细胞的细胞毒性。在这10个化合物中，1和2表现出中等的细胞毒性，IC 50值范围为9.54 - 32.41 μM。
Two new anthraquinones, melrubiellin C (1) and melrubiellin D (2), were isolated from the aerial parts ofMelandrium firmumRohrbach, together with eight known compounds (3–10). The structures of these compounds were elucidated using 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) experiments. All isolated compounds were tested for their cytotoxicity against NCI-H460, Hep G2, MKN-28 and A-549 cells. Of these 10 compounds,1and2exhibited moderate cytotoxicity with IC50values ranging from 9.54 to 32.41 μM.