Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals.
Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals.
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DOI：
10.1016/s0161-6420(84)34248-8
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发表时间：
1984-06
期刊：
影响因子：
13.7
通讯作者：
J. Alvarado;C. Murphy;R. Juster
中科院分区：
文献类型：
--
作者：
J. Alvarado;C. Murphy;R. Juster
比较原发性开角型青光眼（POAG）和非青光眼（NG）患者的小梁网细胞构成（细胞/单位组织面积）。NG标本（n = 69）包括产前（n = 14）和产后至98岁（n = 55）的标本。青光眼样本（n = 49）涵盖了广泛的年龄范围（23-80岁），并在小梁切除术（n = 31）或尸检（n = 18）时获得。我们的研究结果表明，NG标本中的小梁细胞减少最迅速，在胎儿后期和出生后的头几年以非线性的方式。这种细胞结构的快速下降然后减缓，在所研究的98年生命的剩余时间内以近乎线性的方式进行。POAG患者的网状结构在所检查的广泛年龄范围内比正常人具有较低的细胞结构，但两种类型的标本随着年龄的增长细胞结构发生类似的下降。因此，NG和POAG标本的年龄-细胞数曲线彼此平行。细胞的损失以类似梯度的方式发生，其中内部组织受到的影响最大，最外面的组织受到的影响最小。各种统计检验表明，这些细胞结构的变化是非常显著和特异的。这些研究结果相比，角膜内皮细胞的损失，并讨论了POAG的重要临床特征。
The trabecular meshwork cellularity (cells/unit tissue area) was compared in patients with primary open-angle glaucoma (POAG) with that of nonglaucomatous (NG) individuals. The NG specimens (n = 69) include specimens from the prenatal period (n = 14) as well as the postnatal period to age 98 years (n = 55). The glaucoma specimens (n = 49) covered a wide-range of ages (23-80 years) and were obtained at trabeculectomy (n = 31) or at autopsy (n = 18). Our results show that the trabecular cellularity in NG specimens decreases most rapidly and in a nonlinear manner in the late fetal period and for the first few years of postnatal life. This rapid decline in cellularity then slows down to proceed in a nearly linear manner for the remainder of the 98 years of life studied. The meshworks from patients with POAG have a lower cellularity than normals over the wide range of ages examined, but both types of specimens undergo similar declines in cellularity with age. Thus, the age-cellularity curves for both the NG and POAG specimens are parallel to each other. The loss of cells occurs in a gradient-like manner with the inner tissues being most affected and the outermost tissues least affected. A variety of statistical tests show that these changes in cellularity are highly significant and specific. These findings are compared to the loss of endothelial cells in the cornea and they are discussed in relation to the important clinical characteristics of POAG.