Expression of salt hunger in hypophysectomized rats.
Expression of salt hunger in hypophysectomized rats.
复制标题
垂体切除大鼠的盐饥饿表达。
DOI：
10.1159/000125261
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发表时间：
1989
影响因子：
4.1
通讯作者：
McEwen,BS
中科院分区：
文献类型：
--
作者：
Schulkin,J;Angulo,J;Sakai,R;McEwen,BS
在不同的实验条件下，对去垂体腺和完整垂体腺的大鼠进行了盐饥饿的表达测试。结果表明，与垂体正常大鼠相比，去垂体大鼠在钠耗竭、卡托普利或血管紧张素诱导的盐饥饿反应中摄入的盐更少。相反，两组人摄入等量的盐来应对盐皮质激素引起的盐饥饿。虽然两组的钠排泄和血浆钠水平相当，但切除脑垂体区和肝脏的血管紧张素原基因的表达减少。这些结果提示，下丘脑切除大鼠体内钠和肾素-血管紧张素系统引起的盐摄入量减少可能是由于血管紧张素原mRNA水平降低所致。
Hypophysectomized and pituitary-intact rats were tested for their expression of salt hunger under a variety of experimental conditions. The results show that hypophysectomized rats ingest less salt in response to salt hunger induced by sodium depletion, captopril or angiotensin in comparison to pituitary-intact rats. In contrast, both groups ingest the same amount of salt in response to mineralocorticoid-induced salt hunger. While sodium excretion and plasma sodium levels were comparable in the two groups, the angiotensinogen mRNA was reduced by hypophysectomy in several limbic brain regions as well as in the liver. These results suggest that reduced salt intake in response to manipulations of the body sodium and renin-angiotensin system in hypophysectomized rats may result from decreased angiotensinogen mRNA levels.