Ultrathin coatings with change in reactivity over time enable functional in vitro networks of insect neurons
Ultrathin coatings with change in reactivity over time enable functional in vitro networks of insect neurons
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DOI：
10.1002/adma.200800270
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发表时间：
2008-07-17
影响因子：
29.4
通讯作者：
Groll, Juergen
中科院分区：
文献类型：
--
作者：
Reska, Anna;Gasteier, Peter;Groll, Juergen
这不是板球！本发明提供了一种新的涂层系统，其能够在不使用额外的化学交联剂的情况下在无污染环境中共价附着生物分子。伴刀豆球蛋白A在涂层上形成图案，以指导来自蟋蟀Gryllus bimaculatus的神经元的细胞粘附和生长，并首次在体外产生功能性的图案化昆虫神经元网络。
It's just not cricket! A novel coating system that enables covalent attachment of biomolecules in a nonfouling environment without use of additional chemical crosslinkers is presented. Concanavalin A is patterned on the coatings to direct cell adhesion and growth of neurons from the cricket Gryllus bimaculatus and generate functional, patterned in vitro insect neuronal networks for the first time.