Hypoxic Ischemic Encephalopathy: Pathophysiology and Experimental Treatments.
Hypoxic Ischemic Encephalopathy: Pathophysiology and Experimental Treatments.
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DOI：
10.1053/j.nainr.2011.07.004
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发表时间：
2011-09-01
期刊：
影响因子：
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通讯作者：
Brandon DH
中科院分区：
文献类型：
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作者：
Allen KA;Brandon DH
新生儿缺氧缺血性脑病（HIE）是一种严重的出生并发症，影响足月婴儿：40-60%的受影响婴儿在2岁时死亡或有严重残疾。HIE的大多数潜在病理事件是脑血流和向脑的氧输送受损导致的初级和次级能量衰竭的结果。过去，治疗选择仅限于支持性药物治疗。目前，正在新生儿和动物模型中探索几种实验性治疗方法，以改善二次能量衰竭的影响。这篇综述讨论了缺氧缺血性事件的潜在病理生理学影响和正在探索的用于管理新生儿缺氧缺血性脑病的实验性治疗方式。需要进一步的研究来更好地了解实验性治疗的长期影响以及实验性治疗的组合是否可以改善HIE婴儿的结局。
Hypoxic ischemic encephalopathy (HIE) is a serious birth complication affecting full term infants: 40–60% of affected infants die by 2 years of age or have severe disabilities. The majority of the underlying pathologic events of HIE are a result of impaired cerebral blood flow and oxygen delivery to the brain with resulting primary and secondary energy failure. In the past, treatment options were limited to supportive medical therapy. Currently, several experimental treatments are being explored in neonates and animal models to ameliorate the effects of secondary energy failure. This review discusses the underlying pathophysiologic effects of a hypoxic-ischemic event and experimental treatment modalities being explored to manage infants with HIE. Further research is needed to better understand if the long-term impact of the experimental treatments and whether the combinations of experimental treatments can improve outcomes in infants with HIE.