Obesity and HIV: a compounding problem
Obesity and HIV: a compounding problem
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DOI：
10.1080/16070658.2017.1404299
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发表时间：
2018-01-01
影响因子：
1.1
通讯作者：
Spooner, Elizabeth
中科院分区：
文献类型：
--
作者：
Biggs, Chara;Spooner, Elizabeth
目的：在南非德班 Lancers Road 诊所进行了一项横断面研究，以确定未接受 ART 治疗的无症状 HIV 阳性成人的身体成分、血红蛋白、血清白蛋白和血清高敏 C 反应蛋白 (hs-CRP) 水平。方法：对所有参加诊所的符合条件的成人进行了抽样。使用氘稀释来评估身体成分。采用描述性统计、Wilcoxon 秩和检验、卡方检验、Fisher 精确检验和 Spearman 等级相关系数进行数据分析。 结果：共有 84 名参与者（CD4 计数：542.5145 个细胞/mm(3)）入组。平均体重指数 (BMI) 为 29.5 (+/- 6.4) kg/m(2)，平均脂肪质量百分比为 44.9 (+/- 18.7)。超重（26.2%，22/84）和肥胖（46.4%，39/84）患病率较高。平均血红蛋白 (Hb) 水平为 12.0 +/- 1.6 g/dl。轻度、中度和重度贫血分别占 21.4% (18/84)、20.2% (17/84) 和 1.2% (1/84) 的患者。平均白蛋白水平 (36.2 +/- 3.8 g/l) 处于正常的低范围边缘，三分之一 (32.1%, 27/84) 的患者存在白蛋白水平轻度耗尽的情况。平均 hs-CRP 水平 (5.5 +/- 7.2 mg/l) 较高。结论：在这组患者中，消瘦与 HIV 无关，因为超重/肥胖的患病率很高，并且符合南澳的人口趋势。由于超重/肥胖、低白蛋白血症、hs-CRP 水平升高和贫血等复合因素，这些看似健康、无症状的艾滋病毒感染者群体的发病、进展和死亡风险增加。
Objectives: A cross-sectional study was undertaken at Lancers Road Clinic, Durban, South Africa to determine body composition, haemoglobin, serum albumin and serum high sensitivity C-reactive protein (hs-CRP) levels in asymptomatic ART-naive HIV positive adults.Methods: All eligible adults attending the clinic were sampled. Body composition was assessed using deuterium dilution. Descriptive statistics, Wilcoxon rank-sum test, chi-square test, Fisher's exact test and Spearman's rank correlation coefficient were used for data analysis.Results: A total of 84 participants (CD4 count: 542.5145 cell/mm(3)) enrolled. The mean body mass index (BMI) was 29.5 (+/- 6.4) kg/m(2) and the mean fat mass percentage was 44.9 (+/- 18.7). The prevalence of overweight (26.2%, 22/84) and obesity (46.4%, 39/84) was high. Mean haemoglobin (Hb) levels were 12.0 +/- 1.6 g/dl. Mild, moderate and severe anaemia was present in 21.4% (18/84), 20.2% (17/84) and 1.2% (1/84) of patients, respectively. Mean albumin levels (36.2 +/- 3.8 g/l) were on the borderline low range of normal with mildly depleted albumin levels being present in a third (32.1%, 27/84) of patients. The mean hs-CRP levels (5.5 +/- 7.2 mg/l) were high.Conclusion: In this cohort of patients, wasting was not associated with HIV as the prevalence of overweight/obesity was high and followed the population trend in SA. This seemingly well, asymptomatic population of people living with HIV was at an increased risk of morbidity, progression and death due to the compounding factors of overweight/obesity, hypoalbuminemia, raised hs-CRP levels and anaemia.