Carbonate apatite granules with uniformly sized pores that arrange regularly and penetrate straight through granules in one direction for bone regeneration
Carbonate apatite granules with uniformly sized pores that arrange regularly and penetrate straight through granules in one direction for bone regeneration
复制标题
DOI：
10.1016/j.ceramint.2019.05.042
复制
发表时间：
2019-08-15
影响因子：
5.2
通讯作者：
Ishikawa, Kunio
中科院分区：
文献类型：
--
作者：
Hayashi, Koichiro;Munar, Melvin L.;Ishikawa, Kunio
能够解决自体骨移植相关问题的人工骨替代物是必不可少的。本研究采用与天然骨成分相同的大孔碳酸盐磷灰石（CO(3)Ap）颗粒植入兔股骨远端骨骺缺损。然后评估材料吸收和骨再生。通过挤压含氢氧化钙的蜂窝结构棒材，将棒材粉碎成颗粒，碳化成方解石，再由方解石转化成CO(3)Ap，得到大孔颗粒。值得注意的是，hc型大孔在一个方向上完全穿透并跨越CO(3)Ap颗粒的直径，并且排列规则，大小均匀（120 μ m）。它们促进细胞渗透到颗粒中并诱导血管生成。结果，骨重塑在颗粒内部和颗粒表面同时发生。此外，颗粒逐渐被吸收并被骨所取代。因此，在颗粒中引入hc型大孔是促进骨再生的有效途径。
Artificial bone substitutes that can solve the problems associated with autogenous bone grafts are essential. In this study, macroporous carbonate apatite (CO(3)Ap) granules with the same composition as natural bone were implanted into distal epiphysis defects in rabbit femurs. Material resorption and bone regeneration were then evaluated. The macroporous granules were obtained by extruding honeycomb (HC) structure rods containing calcium hydroxide, pulverizing the rods to granules, carbonating them to calcite, and converting them from calcite to CO(3)Ap. Notably, the HC-type macropores fully penetrated and spanned their diameters of the CO(3)Ap granules in one direction, as well as being regularly arranged and uniformly sized (120 mu m). They facilitated cell penetration into the granules and the induction of angiogenesis. As a result, bone remodeling occurred simultaneously within the granules and on the granule surfaces. Furthermore, the granules were gradually resorbed and replaced by bone. Thus, introducing HC-type macropores into granules is an effective approach for promoting bone regeneration.