Splenic lymphoma with villous lymphocytes: Clinical presentation, biology and prognostic factors in a series of 100 patients
Splenic lymphoma with villous lymphocytes: Clinical presentation, biology and prognostic factors in a series of 100 patients
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DOI：
10.1046/j.1365-2141.1996.d01-1711.x
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发表时间：
1996-06-01
影响因子：
6.5
通讯作者：
Flandrin, G
中科院分区：
文献类型：
--
作者：
Troussard, X;Valensi, F;Flandrin, G
细胞学家小组对 100 名患者进行了评估，对伴有绒毛淋巴细胞的脾淋巴瘤 (SLVL) 进行了诊断。分析与预后相关的临床和生物学特征。SLVL 是一种慢性 B 细胞淋巴细胞增殖性疾病，其特征是脾肿大，外周血中存在带有“绒毛”突起的淋巴细胞。对于没有绝对淋巴细胞增多的患者（24% 的病例中观察到这种情况），细胞学诊断可能很困难。 B细胞表达CD19(+)、CD20(+)、CD22+、CD24(+)和DBA44(+)，而CD5、CD10和CD25通常呈阴性表达。SLVL是一种老年人疾病，临床过程相对良性。在本系列中，5 年总生存率为 78%，15 名患者的死亡与疾病进展或治疗有关（9 例），白细胞计数 >30 x 10(9)/l 或淋巴细胞计数的患者
The diagnosis of splenic lymphoma with villous lymphocytes (SLVL) was assessed by a panel of cytologists in a series of 100 patients. Clinical and biological characteristics were analysed in relation to prognosis.SLVL is a chronic B-cell lymphoproliferative disorder characterized by splenomegaly and the presence, in peripheral blood, of lymphocytes with 'villous' projections, The cytological diagnosis can be difficult in patients without an absolute lymphocytosis which was observed in 24% of cases. B-ceIls expressed CD19(+), CD20(+), CD22+, CD24(+) and DBA44(+), whereas the expression of CD5, CD10 and CD25 was usually negative.SLVL is a disease of the elderly with a relatively benign clinical course. In the present series the 5-year overall survival was 78%, Deaths in 15 patients were related to disease progression or treatment (nine cases), Patients with a leucocyte count >30 x 10(9)/l or lymphocyte count