Anterior cingulate cortical lesion attenuates food foraging in rats
Anterior cingulate cortical lesion attenuates food foraging in rats
复制标题
前扣带皮层损伤减弱大鼠的食物觅食
DOI：
10.1016/j.brainresbull.2012.05.015
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发表时间：
2012-09-01
影响因子：
3.8
通讯作者：
Li, Changqi
中科院分区：
文献类型：
--
作者：
Li, Fang;Li, Mingbo;Li, Changqi
We have developed a novel laboratory rodent model to detect competitive, non-competitive and no-hurdle foraging behaviors as seen in natural environment. However, it is not clear which brain region is important for the food foraging activity. In the present study, we evaluated the effect of lesions in the bilateral anterior cingulate cortex (ACC) on the rat food foraging behavior with the established model. In contrast to the sham lesion group (saline microinjection into the ACC), bilateral complete ACC chemical lesions (kainic acid microinjection into the ACC) significantly decreased the amount of foraged food in the competitive food foraging tests, non-competitive or no-hurdle foraging test. Moreover, the deficit of the food foraging activity was more prominent in the competitive food foraging test than in the noncompetitive food and no-hurdle foraging test after ACC lesions. No alterations after ACC lesions were found in other behaviors including elevated plus-maze test (EPM), forced swimming test (FST), open field test (OFT), sucrose preference test and exploratory behavior. These findings suggest that the ACC mediate the food foraging-related behaviors. (C) 2012 Elsevier Inc. All tights reserved.
