CRANIAL IRRADIATION IN CANCER OF THE LUNG OF ALL CELL-TYPES
CRANIAL IRRADIATION IN CANCER OF THE LUNG OF ALL CELL-TYPES
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DOI：
10.1001/jama.245.5.469
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发表时间：
1981-01-01
影响因子：
120.7
通讯作者：
YESNER, R
中科院分区：
文献类型：
--
作者：
COX, JD;STANLEY, K;YESNER, R
1975年至1978年，退伍军人管理局肺科小组对不能手术的肺癌患者进行了一项亚临床脑转移放射治疗的前瞻性研究。患者随机接受全脑照射（2000拉德，2周）或无脑治疗，并接受2个方案的胸部照射之一。对放射性核素脑扫描正常的患者（323例）进行了评价。小细胞癌患者的临床脑转移率为26%，而非小细胞癌患者的临床脑转移率为10%。在小细胞癌的放射治疗患者中，发现脑转移率在统计学上无显著性下降。非小细胞肺癌脑转移的发生率由13%降至6%。预防性头颅照射可降低非小细胞肺癌的发病率。
The Veterans Administration Lung Group conducted a prospective study of irradiation for subclinical brain metastases in patients with inoperable carcinoma of the lung between 1975 and 1978. Patients were randomized to receive whole-brain irradiation (2000 rad in 2 wk) or no brain treatment, and to receive 1 of 2 regimens of thoracic irradiation. Patients with normal radionuclide brain scans (323) were evaluated. The rate of clinical brain metastasis was 26% for patients with small cell carcinoma vs. 10% for the non-small-cell group. A statistically insignificant decrease in the rate of brain metastasis was found among irradiated patients with small cell carcinoma. The frequency of brain metastasis in the non-small-cell patients was reduced from 13% to 6% by irradiation. Prophylactic cranial irradiation can decrease morbidity from non-small-cell carcinoma of the lung.