Simultaneous Measurements of Follicle Stimulating Hormone and Total Testosterone and Associations in Clinically Localized Prostate Cancer.
Simultaneous Measurements of Follicle Stimulating Hormone and Total Testosterone and Associations in Clinically Localized Prostate Cancer.
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DOI：
10.1159/000447177
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发表时间：
2017-11-01
期刊：
影响因子：
1.6
通讯作者：
Artibani, Walter
中科院分区：
文献类型：
--
作者：
Porcaro, Antonio B;Siracusano, Salvatore;Artibani, Walter
目的：探讨临床局限性前列腺癌(PCa)患者前列腺特异性抗原(PSA)、卵泡刺激素(FSH)和总睾酮(TT)同时检测的临床意义。结果：肿瘤体积(TV)与PSA、TT呈正相关，与FSH呈负相关。此外，它与PSA和TT独立相关。在多元线性回归模型中，FSH和TV是与TT同时相关的独立因素，前者与TT呈负相关，后者与TT呈正相关。在患者群体中，FSH水平高于第三个四分位数的亚组与较低的TT中值水平有关，这与高级别癌症相关，显示出较低的TV。在局限型PCa中，TT基础水平与肿瘤参数相关，与FSH水平呈负相关，第三分位数以上的FSH水平与低TT水平相关，且与肿瘤负荷低的高级别肿瘤相关。FSH水平升高的患者与TT水平降低有关，TT水平降低与高级别癌症相关。
OBJECTIVES: To evaluate the potential relations of simultaneous measurements of basal levels of follicle stimulating hormone (FSH) and total testosterone (TT) in clinically localized prostate cancer (PCa).MATERIALS AND METHODS: The study included 126 patients who had simultaneous measurements of prostate specific antigen (PSA), FSH, and TT before undergoing radical prostatectomy for clinically localized PCa. Correlations and independent associations between clinical and pathological factors were investigated by statistical methods.RESULTS: The tumor volume (TV) was directly correlated to PSA and TT which was inversely related to FSH. Moreover, it was independently associated with both PSA and TT. In a multivariate linear regression model, FSH and TV were simultaneous independent factors associated with TT, and the association was inverse in the former and direct in the latter. In the patient population, the subset with FSH levels above the third quartile was related to lower median levels of TT that were associated with high grade cancer showing a lower TV. In localized PCa, basal levels of TT were associated with tumor parameters and inversely related to FSH levels, and the subset FSH levels above the third quartile were related to lower TT levels that were associated with high grade cancers showing a lower tumor load.CONCLUSION: Preoperative TT was associated with tumor parameters and inversely related to FSH levels. Patient with increased FSH levels was related to lower levels of TT, which was associated with high grade cancer.