DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
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DOI：
10.1038/ni829
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发表时间：
2002-09-01
影响因子：
30.5
通讯作者：
Cerutti, A
中科院分区：
文献类型：
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作者：
Litinskiy, MB;Nardelli, B;Cerutti, A
免疫球蛋白（Ig）类转换DNA重组（CSR）被认为高度依赖于CD40配体在T细胞上与B细胞的结合。我们在这里表明树突状细胞在暴露于干扰素- α，干扰素- γ或CD40配体时上调BLyS和APRIL。在白细胞介素10 （IL-10）或转化生长因子- β存在的情况下，BLyS和APRIL在B细胞中诱导CSR从C到C和/或C- α基因，而CSR到C-epsilon则需要IL-4。类转换抗体的分泌需要B细胞抗原受体参与和IL-15的额外刺激。通过诱导不依赖cd40的Ig类转换和浆细胞样分化，BLyS和APRIL将先天免疫反应和适应性免疫反应紧密联系在一起。
Immunoglobulin (Ig) class-switch DNA recombination (CSR) is thought to be highly dependent upon engagement of CD40 on B cells by CD40 ligand on T cells. We show here that dendritic cells upregulate BLyS and APRIL upon exposure to interferon-alpha, interferon-gamma or CD40 ligand. In the presence of interleukin 10 (IL-10) or transforming growth factor-beta, BLyS and APRIL induce CSR from C to C and/or C-alpha genes in B cells, whereas CSR to C-epsilon requires IL-4. Secretion of class-switched antibodies requires additional stimulation by B cell antigen receptor engagement and IL-15. By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses.