Better and faster velocity pulsatility assessment in cerebral white matter perforating arteries with 7T quantitative flow MRI through improved slice profile, acquisition scheme, and postprocessing
Better and faster velocity pulsatility assessment in cerebral white matter perforating arteries with 7T quantitative flow MRI through improved slice profile, acquisition scheme, and postprocessing
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DOI：
10.1002/mrm.26821
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发表时间：
2018-03-01
影响因子：
3.3
通讯作者：
Zwanenburg, Jaco
中科院分区：
文献类型：
--
作者：
Geurts, Lennart;Biessels, Geert Jan;Zwanenburg, Jaco
PurposeA previously published cardiac-gated 2D Qflow protocol at 7T in cerebral perforating arteries was optimized to reduce velocity underestimation and improve temporal resolution.MethodsFirst, the signal-to-noise ratio (SNR) gain of the velocity measurement (SNRv) was tested for two signal averages versus one. Second, the decrease in velocity underestimation with a tilted optimized nonsaturating excitation (TONE) pulse was tested. Third, the decrease in pulsatility index (PI) underestimation through improved temporal resolution was tested. Test-retest agreement was measured for the resulting acquisition in older volunteers (mean age 63 years), and the results were compared with the other volunteers (mean age 26 years).ResultsUsing two signal averages increased SNRv by only 12% (P=0.04), probably due to motion of the subvoxel-size arteries. The TONE decreased velocity underestimation, thereby increasing the mean velocity from 0.52 to 0.67cm/s (P
