A role for inhibition in shaping the temporal flow of information in prefrontal cortex
A role for inhibition in shaping the temporal flow of information in prefrontal cortex
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DOI：
10.1038/nn799
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发表时间：
2002-02-01
影响因子：
25
通讯作者：
Goldman-Rakic, PS
中科院分区：
文献类型：
--
作者：
Constantinidis, C;Williams, GV;Goldman-Rakic, PS
前额叶皮质在引导或抑制未来的反应方面很重要，这需要事件的时间整合，并为思维过程提供连续性。还没有提出任何细胞机制来解释一个反应或想法的心理表征如何与下一个联系在一起。利用猴子的同步记录，我们揭示了不同时间点活跃的神经元之间的抑制性相互作用，这些神经元与工作记忆任务的线索呈现、延迟间隔和反应周期有关。这些发现表明，抑制在大脑皮层中发挥着重要作用--在认知操作中控制神经元活动的时间，从而塑造信息流的时间。
The prefrontal cortex is important in guiding or inhibiting future responses, which requires the temporal integration of events and which provides continuity to the thought process. No cellular mechanism has been proposed to explain how the mental representation of a response or idea is linked to the next. Using simultaneous recordings in monkeys, we revealed inhibitory interactions between neurons active at different time points relative to the cue presentation, delay interval and response period of a working memory task. These findings suggest an important role of inhibition in the cerebral cortex-controlling the timing of neuronal activities during cognitive operations and thereby shaping the temporal flow of information.