Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development
Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development
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DOI：
10.1126/scitranslmed.aay4068
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发表时间：
2020-07-08
影响因子：
17.1
通讯作者：
Shimojo, Naoki
中科院分区：
文献类型：
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作者：
Nakamura, Yuumi;Takahashi, Hiroki;Shimojo, Naoki
特应性皮炎（AD）通常与金黄色葡萄球菌在受影响皮肤中的定植有关。为了了解金黄色葡萄球菌在AD发展中的作用，我们对268名出生后1个月和6个月的日本婴儿的脸颊皮肤分离的金黄色葡萄球菌菌株进行了全基因组测序。大约45%的婴儿在1个月时感染金黄色葡萄球菌，与AD的预后无关。相反，6个月大时金黄色葡萄球菌的皮肤定植增加了患AD的风险。金黄色葡萄球菌Agr群体感应（QS）系统的功能失调突变主要在未发生AD的6个月大婴儿的菌株中观察到。在金黄色葡萄球菌中表达功能性Agr系统是表皮定植和诱导小鼠ad样炎症所必需的。因此，在婴儿期保留功能性金黄色葡萄球菌agr毒力与病原体皮肤定植和AD的发展有关。
Atopic dermatitis (AD) is commonly associated with colonization by Staphylococcus aureus in the affected skin. To understand the role of S. aureus in the development of AD, we performed whole-genome sequencing of S. aureus strains isolated from the cheek skin of 268 Japanese infants 1 and 6 months after birth. About 45% of infants were colonized with S. aureus at 1 month regardless of AD outcome. In contrast, skin colonization by S. aureus at 6 months of age increased the risk of developing AD. Acquisition of dysfunctional mutations in the S. aureus Agr quorum-sensing (QS) system was primarily observed in strains from 6-month-old infants who did not develop AD. Expression of a functional Agr system in S. aureus was required for epidermal colonization and the induction of AD-like inflammation in mice. Thus, retention of functional S. aureus agr virulence during infancy is associated with pathogen skin colonization and the development of AD.