Handwriting movement analyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone
Handwriting movement analyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone
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DOI：
10.1016/j.humov.2009.07.007
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发表时间：
2009-10-01
影响因子：
2.1
通讯作者：
Lohr, James
中科院分区：
文献类型：
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作者：
Caligiuri, Michael P.;Teulings, Hans-Leo;Lohr, James
流行病学研究表明，近 60% 接受传统抗精神病药物治疗的精神分裂症 (SZ) 患者会出现锥体外系副作用 (EPS)，例如帕金森症和迟发性运动障碍。尽管由于新型抗精神病药物的出现，EPS 的患病率有所下降，但 EPS 仍然限制了这些药物的有效性。持续监测 EPS 可能会改善治疗结果或依从性，并减少再住院的频率。手写运动学的定量分析用于评估抗精神病药物类型和剂量对精神分裂症患者的影响。纳入了 27 名接受利培酮治疗的精神分裂症患者、6 名未接受抗精神病药物治疗的精神分裂症患者以及 47 名健康对照参与者。参与者执行了 20 分钟的手写任务，其中包括不同大小的循环和一个句子。使用 MovAlyzeR 软件捕获和分析数据。结果表明，接受利培酮治疗的参与者比健康或未经治疗的 SZ 参与者表现出明显更不流畅的书写动作。与未接受药物治疗的患者相比，接受利培酮治疗的参与者在制作简单循环期间表现出较低的运动速度。句子书写期间的书写不流畅随着剂量的增加而增加。由句子书写得出的运动学变量组成的三因素模型占药物剂量变异性的 83% (r = .91)。相比之下。我们发现基于观察者的 EPS 严重程度评级与药物剂量之间没有关联。这些发现支持了基于手写的测量方法对于监测药物精神分裂症患者 EPS 的重要性。 (C) 2009 Elsevier B.V. 保留所有权利。
Epidemiologic studies indicate that nearly 60% of schizophrenia (SZ) patients treated with conventional antipsychotic drugs develop extrapyramidal side effects (EPS) such as parkinsonism and tardive dyskinesia. Although the prevalence of EPS has decreased due to the newer antipsychotics, EPS continue to limit the effectiveness of these medicines. Ongoing monitoring of EPS is likely to improve treatment outcome or compliance and reduce the frequency of re-hospitalization. A quantitative analysis of handwriting kinematics was used to evaluate effects of antipsychotic medication type and dose in schizophrenia patients. Twenty-seven schizophrenia patients treated with risperidone, six schizophrenia patients who received no antipsychotic medication and 47 healthy comparison participants were enrolled. Participants performed a 20-min handwriting task consisting of loops of various sizes and a sentence. Data were captured and analyzed using MovAlyzeR software. Results indicated that risperidone-treated participants exhibited significantly more dysfluent handwriting movements than either healthy or untreated SZ participants. Risperidone-treated participants exhibited lower movement velocities during production of simple loops compared to unmedicated patients. Handwriting dysfluency during sentence writing increased with dose. A 3-factor model consisting of kinematic variables derived from sentence writing accounted for 83% (r = .91) of the variability in medication dose. In contrast. we found no association between observer-based EPS severity ratings and medication dose. These findings support the importance of handwriting-based measures to monitor EPS in medicated schizophrenia patients. (C) 2009 Elsevier B.V. All rights reserved.