Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma.
Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma.
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发表时间：
2000-12
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通讯作者：
Y. Honjo;Hidenori Inohara;Shiro Akahani;T. Yoshii;Y. Takenaka;Junpei Yoshida;K. Hattori;Y. Tomiyama-Y.-To
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作者：
Y. Honjo;Hidenori Inohara;Shiro Akahani;T. Yoshii;Y. Takenaka;Junpei Yoshida;K. Hattori;Y. Tomiyama-Y.-To
Galectin-3 是 β-半乳糖苷结合哺乳动物凝集素家族的成员，对 ABH 组表位、细胞表面和细胞外聚乳糖胺聚糖具有亲和力。它已被证明参与分化、形态发生、肿瘤进展和转移。在此，我们质疑半乳糖凝集素 3 是否可能参与舌上皮肿瘤进展，并评估其对舌癌患者的预后价值。采用免疫组织化学方法分析 77 例舌标本（54 例鳞状细胞癌和 23 例不同正常粘膜标本）中 Galectin-3 的表达。从正常状态到癌变状态，galectin-3的核表达水平显着降低（P < 0.0001），而细胞质表达水平增加（P < 0.0001）。细胞质中半乳糖凝集素 3 的表达增强与舌癌患者的无病生存期缩短有关。多变量分析确定细胞质半乳糖凝集素 3 表达增强是疾病复发的独立预测因子 (P = 0.0120)。这些结果表明，在肿瘤进展过程中观察到的半乳糖凝集素-3从细胞核到细胞质的易位可能作为舌癌患者的预后因素。
Galectin-3 is a member of the beta-galactoside-binding mammalian lectin family with affinity to ABH group epitopes, cell surface and extracellular polylactosamine glycans. It has been shown to be involved in differentiation, morphogenesis, tumor progression, and metastasis. Here we questioned the possible involvement of galectin-3 in the neoplastic progression of the tongue epithelium and evaluated its prognostic value in tongue cancer patients. Galectin-3 expression was analyzed by the immunohistochemical method in 77 tongue specimens (54 squamous cell carcinomas and 23 specimens of distinct normal mucosa). Levels of nuclear expression of galectin-3 markedly decreased during the progression from normal to cancerous states (P < 0.0001), while cytoplasmic expression increased (P < 0.0001). Enhanced expression of galectin-3 in the cytoplasm was associated with a reduced disease-free survival of tongue cancer patients. Multivariate analysis identified enhanced expression of cytoplasmic galectin-3 as an independent predictor of disease recurrence (P = 0.0120). These results suggest that the observed translocation of galectin-3 from the nucleus to the cytoplasm during neoplastic progression may serve as a prognostic factor for tongue cancer patients.