Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.
Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.
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DOI：
10.1073/pnas.84.10.3316
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发表时间：
1987-05
影响因子：
11.1
通讯作者：
P. Vogt;T. Bos;R. Doolittle
中科院分区：
文献类型：
--
作者：
P. Vogt;T. Bos;R. Doolittle
最近描述的癌基因jun的产物显示出与GCN 4酵母转录激活蛋白显著的氨基酸序列同源性。相似性仅限于66个羧基末端氨基酸，被认为是GCN 4蛋白的DNA结合结构域。在这些α-螺旋的jun和GCN 4产品的允许区域也有一个较小的，但仍然显着的氨基酸相似性的fos蛋白和边际程度的相似性myc蛋白。GCN 4和jun基因产物之间的氨基酸序列同源性表明，jun蛋白可能以序列特异性的方式与DNA结合并发挥调节功能。
The product of the recently described oncogene jun shows significant amino acid sequence homology with the GCN4 yeast transcriptional activator protein. The similarity is restricted to the 66 carboxyl-terminal amino acids, thought to be the DNA-binding domain of the GCN4 protein. In these alpha-helix-permissive regions of the jun and GCN4 products there is also a lesser but still significant amino acid resemblance to the fos protein and a marginal degree of similarity to myc proteins. The amino acid sequence homology between GCN4 and jun gene products suggests that the jun protein may bind to DNA in a sequence-specific way and exert a regulatory function.