Regulation of inflammation by short chain fatty acids.
Regulation of inflammation by short chain fatty acids.
复制标题
用短链脂肪酸调节炎症。
作者：
Vinolo MA;Rodrigues HG;Nachbar RT;Curi R
短链脂肪酸（SCFAs）乙酸酯（C2）、丙酸酯（C3）和丁酸酯（C4）是肠道厌氧细菌发酵的主要代谢产物。除了作为肠上皮细胞的燃料的重要作用外，SCFA还调节胃肠道（GI）中的不同过程，如电解质和水的吸收。这些脂肪酸被认为是参与肠道微生物群对肠道免疫功能影响的潜在介质。SCFA通过至少两种机制作用于白细胞和内皮细胞：GPCR（GPR 41和GPR 43）的活化和组蛋白脱乙酰酶（HDAC）的活化。SCFA调节几种白细胞功能，包括细胞因子（TNF-α、IL-2、IL-6和IL-10）、类花生酸和趋化因子（例如，MCP-1和CINC-2）。白细胞迁移到炎症病灶和破坏微生物病原体的能力似乎也受到SCFA的影响。本文就SCFAs调控炎症过程的最新研究进展作一综述。这些脂肪酸对分离的细胞（白细胞，内皮细胞和肠上皮细胞），特别是对白细胞的招募和激活的影响进行了讨论。还强调了这些脂肪酸用于治疗炎性病理的治疗应用。
The short chain fatty acids (SCFAs) acetate (C2), propionate (C3) and butyrate (C4) are the main metabolic products of anaerobic bacteria fermentation in the intestine. In addition to their important role as fuel for intestinal epithelial cells, SCFAs modulate different processes in the gastrointestinal (GI) tract such as electrolyte and water absorption. These fatty acids have been recognized as potential mediators involved in the effects of gut microbiota on intestinal immune function. SCFAs act on leukocytes and endothelial cells through at least two mechanisms: activation of GPCRs (GPR41 and GPR43) and inhibiton of histone deacetylase (HDAC). SCFAs regulate several leukocyte functions including production of cytokines (TNF-α, IL-2, IL-6 and IL-10), eicosanoids and chemokines (e.g., MCP-1 and CINC-2). The ability of leukocytes to migrate to the foci of inflammation and to destroy microbial pathogens also seems to be affected by the SCFAs. In this review, the latest research that describes how SCFAs regulate the inflammatory process is presented. The effects of these fatty acids on isolated cells (leukocytes, endothelial and intestinal epithelial cells) and, particularly, on the recruitment and activation of leukocytes are discussed. Therapeutic application of these fatty acids for the treatment of inflammatory pathologies is also highlighted.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
4.6
作者：
Böcker, U;Nebe, T;Singer, MV
通讯作者：
Singer, MV
DOI：
10.1179/096805100101532108
发表时间：
2000-01-01
期刊：
JOURNAL OF ENDOTOXIN RESEARCH
影响因子：
--
作者：
Chakravortty, D;Koide, N;Yokochi, T
通讯作者：
Yokochi, T
影响因子：
4.8
作者：
Brown, AJ;Goldsworthy, SM;Dowell, SJ
通讯作者：
Dowell, SJ
影响因子：
5.7
作者：
Fusunyan, RD;Quinn, JJ;Sanderson, IR
通讯作者：
Sanderson, IR