Expression of Keratin 19 Is Related to High Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation
Expression of Keratin 19 Is Related to High Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation
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DOI：
10.1159/000328448
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发表时间：
2011-01-01
期刊：
影响因子：
3.5
通讯作者：
Izumi, Namiki
中科院分区：
文献类型：
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作者：
Tsuchiya, Kaoru;Komuta, Mina;Izumi, Namiki
目的：角蛋白(K) 19阳性已被报道为肝切除术后肝细胞癌（HCC）患者复发的有用预测指标。我们研究了K19阳性在接受治疗性射频消融（RFA）患者中的临床应用价值。方法：我们回顾性评估246例符合米兰标准并接受治疗性RFA的HCC患者的临床病理特征，包括影像学和K19表达。使用两步插入法，在RFA之前获得肿瘤活检并进行组织学评估。结果：未观察到肝活检和射频消融引起的肿瘤播散。k19阳性HCC 10例（4.1%）。k19阳性和阴性HCC的影像学表现相似（p = 0.187）。10例k19阳性HCC患者中有9例（90%）在RFA后HCC复发，10例中有6例（60.0%）在12个月内肝内复发。K19阳性是复发（p < 0.0001）和早期复发（p < 0.0001）的重要危险因素。
Objective: Keratin (K) 19 positivity has been reported to be a useful predictive marker for recurrence in patients with hepatocellular carcinoma (HCC) who have undergone hepatic resection. We investigated the clinical usefulness of K19 positivity in patients who had received curative radiofrequency ablation (RFA). Methods: We retrospectively evaluated the clinicopathological features, including imaging and K19 expression, in 246 patients with HCC who were within the Milan criteria and had received curative RFA. Using a two-step insertion method, tumor biopsies were obtained just prior to RFA and were evaluated histologically. Results: Tumor seeding due to liver biopsy and RFA was not observed. Ten patients (4.1%) had K19-positive HCC. Imaging findings were similar between K19-positive and -negative HCC (p = 0.187). Nine out of 10 patients (90%) who had K19-positive HCC had recurrence of HCC after RFA, and intrahepatic recurrences were observed within 12 months in 6 out of 10 (60.0%). K19 positivity was a significant risk factor for recurrence (p < 0.0001) and early recurrence (