Markedly elevated specific renin levels in the adrenal in genetically hypertensive rats.
Markedly elevated specific renin levels in the adrenal in genetically hypertensive rats.
复制标题
遗传性高血压大鼠肾上腺中特定肾素水平显着升高。
DOI：
10.1073/pnas.79.10.3295
复制
发表时间：
1982
影响因子：
11.1
通讯作者：
T. Inagami
中科院分区：
文献类型：
--
作者：
M. Naruse;T. Inagami
自发性高血压大鼠肾上腺中的特异性肾素（EC 3.4.99.19）活性通过一种方法测定，该方法能够通过使用肾素特异性抗体区分蛋白酶的肾素与非特异性肾素样活性。成年自发性高血压大鼠肾上腺中的肾素水平是正常血压对照大鼠的6-8倍。即使在尚未发生高血压的3周龄大鼠中也观察到肾上腺肾素水平的巨大差异。在高血压和血压正常的菌株中，双侧肾切除术均使肾上腺肾素水平升高。大量的肾素被发现在肾上腺皮质比髓质，和高血压应变和正常应变之间的差异更突出的皮质比髓质。这些结果表明，可能参与的发展和高血压的早期维持阶段，在这种动物模式的人类原发性高血压的肾上腺皮质或肾上腺髓质的活动，或两者兼而有之。
The specific renin (EC 3.4.99.19) activity in the adrenal of spontaneously hypertensive rats was determined by a method that is capable of distinguishing renin from nonspecific renin-like activity of proteases by using specific antibody to renin. The renin level in the adrenals of adult spontaneously hypertensive rats with established hypertension was found to be 6-8 times as high as that of the normotensive control Wistar-Kyoto strain. The large difference in the adrenal renin level was observed even in 3-wk-old rats in which hypertension has not yet developed. The adrenal renin level was increased by bilateral nephrectomy in both the hypertensive and normotensive strains. A larger quantity of renin was found in the adrenal cortex than in the medulla, and the difference between the hypertensive strain and the normotensive strain was more prominent in the cortex than in the medulla. These results suggest possible involvement of adrenal renin in the development and in the early maintenance phase of hypertension in this animal mode of human essential hypertension by affecting the adrenocortical or adrenomedullary activity, or both.