Control of excitatory and inhibitory synapse formation by neuroligins
Control of excitatory and inhibitory synapse formation by neuroligins
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DOI：
10.1126/science.1107470
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发表时间：
2005-02-25
期刊：
影响因子：
56.9
通讯作者：
Scheiffele, P
中科院分区：
文献类型：
--
作者：
Chih, B;Engelman, H;Scheiffele, P
神经网络的正常功能依赖于兴奋性和抑制性突触输入之间的微妙平衡。突触的形成被认为是由突触前和突触后细胞之间的双向信号调节的。我们证明，神经连接素家族的成员促进培养的大鼠海马神经元突触后分化。通过RNA干扰下调神经连接素同种型表达导致兴奋性和抑制性突触的丧失。电生理学分析显示抑制性突触功能显著减少。因此，神经胶质控制海马神经元中兴奋性和抑制性突触的形成和功能平衡。
The normal function of neural networks depends on a delicate balance between excitatory and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional signaling between pre- and postsynaptic cells. We demonstrate that members of the Neuroligin family promote postsynaptic differentiation in cultured rat hippocampal neurons. Down-regulation of neuroligin isoform expression by RNA interference results in a loss of excitatory and inhibitory synapses. Etectrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons.