Predictors of Depressive Mood in Patients With Isolated Cerebellar Stroke: A Retrospective Study.
Predictors of Depressive Mood in Patients With Isolated Cerebellar Stroke: A Retrospective Study.
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DOI：
10.5535/arm.2016.40.3.412
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发表时间：
2016-06
期刊：
影响因子：
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通讯作者：
Kim YW
中科院分区：
文献类型：
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作者：
Koh DJ;Kim NY;Kim YW
目的：探讨孤立性小脑卒中患者抑郁情绪的预测因素。对2002-2014年间首次发生孤立性小脑卒中的患者进行了回顾性图表回顾。根据老年抑郁量表(GDS)将患者分为两组(非抑郁组0≤GDS≤16；抑郁组17≤GDS≤30)。收集了有关人口统计和社会经济因素、合并症、功能水平、认知和语言功能以及中风特征的数据。对单因素分析中的显著变量进行Logistic回归分析。55.8%的患者有抑郁情绪，年龄较大(p=0.021)，高血压患病率较高(p=0.014)。认知和语言功能在两组之间没有差异。多因素Logistic回归分析显示，抑郁组的缺血性卒中发生率较高(p=0.035)，右侧小脑后半球病变占主导地位(p=0.028)，与抑郁情绪独立相关(优势比5.081；95%可信区间1.261-20.479)。有高血压、缺血性中风和右小脑后半球病变的老年患者发生小脑中风后抑郁情绪的风险增加。最显著的决定因素是右侧小脑后半球的卒中病变。早期发现危险因素对于预防和管理小脑中风后的抑郁情绪非常重要。
To identify predictive factors of depressive mood in patients with isolated cerebellar stroke. A retrospective chart review was performed in patients who had experienced their first isolated cerebellar stroke during 2002–2014. The patients were classified into two groups by the Geriatric Depression Scale (GDS) (non-depressive group, 0≤GDS≤16; depressive group, 17≤GDS≤30). Data on demographic and socioeconomic factors, comorbidities, functional level, cognitive and linguistic function, and stroke characteristics were collected. Significant variables in univariate analysis were analyzed using logistic regression. Fifty-two patients were enrolled, of whom 55.8% had depressive mood, were older (p=0.021), and had higher hypertension rates (p=0.014). Cognitive and linguistic functions did not differ between the two groups. The depressive group had higher ischemic stroke rates (p=0.035) and showed a dominant right posterior cerebellar hemisphere lesion (p=0.028), which was independently associated with depressive mood in the multiple logistic regression analysis (odds ratio, 5.081; 95% confidence interval, 1.261–20.479). The risk of depressive mood after cerebellar stroke was increased in patients at old age, with a history of hypertension, ischemic stroke, and lesion of the right posterior cerebellar hemisphere. The most significant determining factor was stroke lesion of the right posterior cerebellar hemisphere. Early detection of risk factors is important to prevent and manage depressive mood after cerebellar stroke.