Preserved spatial memory after hippocampal lesions: effects of extensive experience in a complex environment
Preserved spatial memory after hippocampal lesions: effects of extensive experience in a complex environment
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DOI：
10.1038/nn1401
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发表时间：
2005-04
影响因子：
25
通讯作者：
G. Winocur;G. Winocur;Morris Moscovitch;M. Moscovitch;S. Fogel;R. Rosenbaum;M. Sekeres
中科院分区：
文献类型：
--
作者：
G. Winocur;G. Winocur;Morris Moscovitch;M. Moscovitch;S. Fogel;R. Rosenbaum;M. Sekeres
海马损伤通常会损害动物的空间学习和记忆，但海马损伤的人保留了对发病前熟悉环境的空间记忆。我们发现，和人类一样，在复杂环境中饲养的正常大鼠，然后给予海马损伤，保留了对该环境的非中心空间记忆。这些结果排除了对单一线索、地标或特定路线的依赖，表明广泛的病前经验导致了独立于海马体的空间表征。
Damage to the hippocampus typically impairs spatial learning and memory in animals, but humans with hippocampal lesions retain spatial memories of premorbidly familiar environments. We showed that, like humans, normal rats reared in a complex environment and then given hippocampal lesions retained allocentric spatial memory for that environment. These results, which ruled out dependency on single cues, landmarks or specific routes, suggest that extensive premorbid experience leads to spatial representations that are independent of the hippocampus.