Innate link between NF-κB activity and ubiquitin-like modifiers
Innate link between NF-κB activity and ubiquitin-like modifiers
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DOI：
10.1042/bst0360853
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发表时间：
2008-10-01
影响因子：
3.9
通讯作者：
Rodriguez, Manuel S.
中科院分区：
文献类型：
--
作者：
Lang, Valerie;Rodriguez, Manuel S.
在由泛素和泛素样蛋白调节的多种信号传导途径中，激活 NF-kappa B（核因子 kappa B）的信号传导途径无疑是最具有特征的信号传导途径之一。泛素家族成员对该转录因子活性的调节发生在不同的水平上，对安全性施加了重叠的控制，其复杂性令人着迷。活性大分子复合物（例如 IKK [I kappa B（抑制性 kappa B）激酶]复合物）的形成受到这些翻译后修饰的严格调节，这可能是由于许多信号会聚在该信号的环形交叉口上。另外一个非常重要的 NF-κ B 控制水平是通过泛素蛋白酶体途径对前体分子和抑制剂分子进行部分或全部蛋白水解而实现的。该水平的监管涉及泛素、SUMO（小泛素相关修饰剂）和 NEDD8 的各种结合和解结合活性。在这里，我们总结了其中一些事件，并强调了互连泛素和泛素样缀合途径的重要性，这些途径决定了这一关键转录因子的活性状态。
Among the several signalling pathways regulated by ubiquitin and ubiquitin-like proteins, the one activating NF-kappa B (nuclear factor kappa B) is certainly one of the best characterized. The regulation of the activity of this transcription factor by members of the ubiquitin family occurs at various levels, imposing overlapping controls of security of intriguing complexity. The formation of active macromolecular complexes such as the IKK [I kappa B (inhibitory kappa B) kinase] complex is tightly regulated by these post-tiranslational modifications probably due to the fact that many signals converge on this signal's roundabout. An additional, very important level of NF-kappa B control occurs through the partial or total proteolysis of precursor and inhibitor molecules exerted by the ubiquitin-proteasome pathway. Regulation at this level implicates various conjugating and de-conjugating activities for ubiquitin, SUMO (small ubiquitin-related modifier) and NEDD8. Here, we summarize some of these events and underline the importance of the interconnecting ubiquitin and ubiquitin-like conjugating pathways that determine the status of the activity of this critical transcription factor.