Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma
Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma
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DOI：
10.1016/j.clim.2015.02.016
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发表时间：
2015-06-01
影响因子：
8.6
通讯作者：
Ichimiya, Shingo
中科院分区：
文献类型：
--
作者：
Karnekura, Ryuta;Shigehara, Katsunori;Ichimiya, Shingo
变应性鼻炎（AR）是最常见的气道过敏性疾病，常伴有支气管哮喘。然而，关于AR进展为AR与支气管哮喘共病（AR +哮喘）的机制知之甚少。为了确定AR和AR +哮喘的病理生理学特征，我们检测了AR和AR +哮喘患者外周血中滤泡辅助性T（Tfh）细胞和调节性B（布雷格）细胞的亚群。结果显示，在AR和AR +哮喘病例中，Tfh细胞亚群中的Tfh 2细胞发生极化。有趣的是，总B细胞中的%布雷格细胞在AR病例中减少，并且在AR +哮喘病例中更广泛地减少。此外，我们发现呼出气一氧化氮和血液嗜酸性粒细胞水平的分数与每%布雷格细胞的Tfh 2细胞指数显著相关。提示在Tfh 2细胞偏斜的情况下，布雷格细胞的相对减少可能是AR对支气管哮喘的加重因素。(C)2015年，作者。爱思唯尔公司出版
Allergic rhinitis (AR), the most common allergic disorder of the airway, is often accompanied by bronchial asthma. However, little is known about the mechanism by which AR advances to AR comorbid with bronchial asthma (AR + Asthma). To determine the pathophysiologic features of AR and AR + Asthma, we examined subsets of follicular helper T (Tfh) cells and regulatory B (Breg) cells in peripheral blood from AR and AR + Asthma patients. The results showed polarization of Tfh2 cells within Tfh cell subsets in both AR and AR + Asthma cases. Interestingly, the %Breg cells in total B cells were decreased in AR cases and, more extensively, in AR + Asthma cases. Moreover, we found significant correlations of fractional exhaled nitricoxide and blood eosinophil levels with the index %Tfh2 cells per %Breg cells. Our findings indicate that relative decrease in Breg cells under the condition of Tfh2 cell skewing is a putative exaggerating factor of AR to bronchial asthma. (C) 2015 The Authors. Published by Elsevier Inc.