Virtual Breast Quasi-static Elastography (VBQE).
Virtual Breast Quasi-static Elastography (VBQE).
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DOI：
10.1177/0161734616662227
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发表时间：
2017-03
影响因子：
2.3
通讯作者：
Jiang J
中科院分区：
文献类型：
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作者：
Rosen D;Wang Y;Jiang J
粘弹性成像（VEI）已被提出来测量弛豫时间常数的表征在体内乳腺病变。在该技术中，对被成像的组织的外部压缩力保持固定的时间段以引起应变蠕变。然后利用超声回波信号的序列来生成时间分辨的应变测量。可以通过将局部时间分辨应变测量值拟合到粘弹性组织模型（例如，修改的Kevin-Voigt模型）来获得弛豫时间常数。在这项研究中，我们的主要目标是定量评估对比度传递效率（CTE）的VEI，其中包含有用的信息，图像解释。使用虚拟乳房准静态弹性成像（VBQE）的开源模拟器，我们进行了VEI对比传输效率的案例研究。在多个三维数值乳房体模包含不同程度的异质性，有限元（FE）模拟结合准线性粘弹性本构组织模型进行模拟数据采集VEI徒手扫描。我们的结果表明，在CTE中存在损耗，并且损耗可以高达-18dB。FE结果还定性证实了临床观察结果，例如组织界面周围的伪影。
Viscoelasticity Imaging (VEI) has been proposed to measure relaxation time constants for characterization of in-vivo breast lesions. In this technique, external compression forces on tissue being imaged are maintained for a fixed period of time to induce strain creep. A sequence of ultrasound echo signals are then utilized to generate time-resolved strain measurements. Relaxation time constants can be obtained by fitting local time-resolved strain measurements to a viscoelastic tissue model (e.g. a modified Kevin-Voigt model). In this study, our primary objective is to quantitatively evaluate the contrast transfer efficiency (CTE) of VEI, which contains useful information regarding image interpretations. Using an open-source simulator for virtual breast quasi-static elastography (VBQE), we conducted a case study of contrast transfer efficiency of VEI. In multiple three-dimensional numerical breast phantoms containing various degrees of heterogeneity, finite element (FE) simulations in conjunction with quasi-linear viscoelastic constitutive tissue models were performed to mimic data acquisition of VEI under freehand scanning. Our results suggested that there were losses in CTE and the losses could be as high as -18 dB. FE results also qualitatively corroborated clinical observations, e.g. artifacts around tissue interfaces.