Patterns of Ganglion Cell Complex and Nerve Fiber Layer Loss in Nonarteritic Ischemic Optic Neuropathy by Fourier-Domain Optical Coherence Tomography
Patterns of Ganglion Cell Complex and Nerve Fiber Layer Loss in Nonarteritic Ischemic Optic Neuropathy by Fourier-Domain Optical Coherence Tomography
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DOI：
10.1167/iovs.11-9300
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发表时间：
2012-07-01
影响因子：
4.4
通讯作者：
Sadun, Alfredo A.
中科院分区：
文献类型：
--
作者：
Aggarwal, Divya;Tan, Ou;Sadun, Alfredo A.
目的。采用傅里叶域光学相干断层扫描（FD-OCT）表征非动脉性缺血性视神经病变（NAION）中神经纤维层（NFL）和神经节细胞复合体（GCC）的损失。诊断为NAION的患者入组，并根据瑞典交互式阈值算法30-2消色差视野（VF）测试分为“高级视野丧失（SFL）”、“下视野丧失（IFL）”和“双半球视野丧失（BFL）”组。就诊6个月后，对患者进行FD-OCT扫描，绘制乳头周围NFL和黄斑GCC的厚度。从青光眼高级成像研究（www.AIGStudy.net）的参与者中选择年龄匹配的正常人。偏差图被定义为厚度图和平均法线图之间的差异。使用Pearson相关系数评估VF与OCT测量之间的相关性。分析了20名受试者的25只NAION眼。大多数（2/3）SFL病例表现为较差的NFL损失，鼻间损失的保留程度不同。所有（4/4）IFL病例均表现出严重的NFL损失，鼻间延伸变化。GCC地图显示了与VFs一致的清晰的半球损失模式。即使在受影响较小的半球也可以检测到NFL和GCC的损失（P < 0.001）。NFL和GCC在总体平均值和上下半球差异方面与VF高度相关（P < 0.001）。NFL和GCC的损失与VF的损失在大小和位置上都有很好的相关性。半球GCC损失与垂直VF损失相关，这种模式可能具有诊断价值。FD-OCT可用于评价NAION。（中国眼科杂志，2012;53:4539-4545）DOI: 10.1167/iovs.11-9300
PURPOSE. To characterize by Fourier-domain optical coherence tomography (FD-OCT) the loss of nerve fiber layer (NFL) and ganglion cell complex (GCC) in nonarteritic ischemic optic neuropathy (NAION).METHODS. Patients diagnosed with NAION were enrolled and categorized into "superior field loss (SFL),'' "inferior field loss (IFL),'' and "bihemispheric field loss (BFL)'' groups based on the Swedish interactive threshold algorithm 30-2 achromatic visual field (VF) tests. Six months after presentation, they were scanned by FD-OCT to map peripapillary NFL and macular GCC thicknesses. Age-matched normals were selected from participants in the Advanced Imaging for Glaucoma Study (www.AIGStudy.net). Deviation maps were defined as the difference between the thickness maps and the average normal maps. Pearson's correlation coefficient was used to assess the correlation between VF and OCT measurements.RESULTS. Twenty-five NAION eyes in 20 subjects were analyzed. Most (2/3) SFL cases showed inferior NFL loss with variable sparing of inferonasal losses. All (4/4) IFL cases showed superior NFL loss with variable inferonasal extension. The GCC maps demonstrated clear hemispheric loss pattern in agreement with VFs. NFL and GCC losses could be detected even in the less affected hemispheres (P < 0.001). NFL and GCC were highly correlated (P < 0.001) with VF in terms of both overall averages and superior-inferior hemispheric differences.CONCLUSIONS. NFL and GCC losses correlated well with VF losses in bothmagnitude and location. Hemispheric GCC loss correlated with altitudinal VF loss and this patternmay be of diagnostic value. FD-OCT is useful in the evaluation of NAION. (Invest Ophthalmol Vis Sci. 2012; 53: 4539-4545) DOI: 10.1167/iovs.11-9300