Influence of diabetes on peripheral bone mineral density in men: a controlled study
Influence of diabetes on peripheral bone mineral density in men: a controlled study
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DOI：
10.1007/s00592-005-0183-1
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发表时间：
2005-06-01
影响因子：
3.8
通讯作者：
Kelly, CA
中科院分区：
文献类型：
--
作者：
Bridges, MJ;Moochhala, SH;Kelly, CA
本研究的目的是：(1)比较糖尿病男性与非糖尿病男性的外周骨密度（BMD），(2)探索可能预测糖尿病男性骨密度的因素。90名男性2型糖尿病患者和35名男性1型糖尿病患者通过计算机化数据库随机入选。还招募了50名健康男性。所有患者均采用双能x线骨密度仪（DEXA）在非优势桡骨远端测量外周骨密度。关于一些临床参数的信息是通过直接询问和从患者病例记录中获得的。1型糖尿病组、2型糖尿病组和对照组的平均年龄（95%可信区间（CI））分别为：49.3岁（44.6 ~ 53.9岁）、62.8岁（60.7 ~ 64.8岁）和38.5岁（34.9 ~ 42.1岁）。三组的中位（95% CI） z分数分别为：-0.18（-0.68至+0.32）、+0.19（-0.14至+0.49）和-0.02(-0.4至+0.31)（p=无统计学意义）。1型糖尿病组仅BMI与BMD相关，2型糖尿病组仅BMI和年龄与BMD相关。在两组糖尿病患者中，骨密度与糖化血红蛋白浓度（HbA(1)c）、病程或微血管或大血管并发症之间没有相关性。我们没有发现1型糖尿病患者、2型糖尿病患者和对照组的外周骨密度有任何显著差异。
The aims of the study were to (1) compare peripheral bone mineral density (BMD) in men with diabetes to peripheral BMD in non-diabetic men, and (2) explore factors which may predict BMD in diabetic men. Ninety men with type 2 diabetes and 35 men with type 1 diabetes were randomly selected for participation via a computerised database. Fifty healthy males were also recruited. All patients had peripheral BMD measured by dual energy Xray absorptiometry (DEXA) at the non-dominant distal radius. Information on a number of clinical parameters was obtained by direct questioning, and from patient case notes. The mean age (95% confidence interval (CI)) of the type 1 diabetic group, type 2 diabetic group and control group were, respectively: 49.3 years (44.6-53.9), 62.8 years (60.7-64.8) and 38.5 (34.9-42.1) years. Median (95% CI) Z-scores for the three groups were: -0.18 (-0.68 to +0.32), +0.19 (-0.14 to +0.49) and -0.02 (-0.4 to +0.31), respectively (p=not significant). Only body mass index (BMI) was correlated with BMD in the type 1 diabetic group, and only BMI and age were correlated with BMD in type 2 diabetics. There was no correlation between BMD and glycosylated haemoglobin concentration (HbA(1)c), disease duration or presence of microvascular or macrovascular complications in either of the diabetic groups. We did not find any significant difference in peripheral BMD between patients with type 1 diabetes, type 2 diabetes and controls.