[Treatment of olfactory neuroblastoma: a report of 14 cases].
[Treatment of olfactory neuroblastoma: a report of 14 cases].
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嗅神经母细胞瘤14例治疗报告[J].
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
Tu Mc
中科院分区：
文献类型：
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作者：
Tu Mc
嗅觉神经母细胞瘤是一种发生于鼻腔的罕见恶性肿瘤。从1982年到1987年，该院共收治了14例病例。平均年龄34岁，15 ~ 65岁，男女比例为1:1。诊断时，3例为轻度a期，仅累及鼻腔；5例为b期，累及鼻腔及一个或多个鼻窦；6例为c期，累及鼻腔以外，包括眼眶、颅底或颅内腔，或转移至颈结或远处部位。所有人都接受了放射治疗，7人也接受了手术治疗。3年和5年生存率分别为50%和30%。7名患者死亡，其中6名是因为一年内的远处转移。它表明这种疾病从一开始就具有侵袭性，并且易于早期转移。提出了预防性宫颈结照射联合化疗的治疗方案。
Olfactory neuroblastoma is a rare malignant tumor arising from the nasal cavity. From 1982 to 1987 fourteen cases had been treated in this hospital. The average age was 34 years with a range from 15 to 65 years, male to female ratio was 1:1. At the time of diagnosis, 3 tumors were of kadish stage A-involvement of the nasal cavity only, 5 of stage B-involvement of the nasal cavity and one or more paranasal sinuses, and six of stage C-extension beyond the nasal cavity, including the orbit, base of skull or intracranial cavity, or metastasis to cervical nodes or distant sites. All were treated with radiation therapy and 7 also by surgery. The three and five-year survival rates were 50% and 30% respectively. Seven patients died, six because of distant metastases within one year. It shows that the disease is aggressive from the beginning, and tends to metastasize early. A treatment regimen for prophylactic cervical node irradiation combining chemotherapy is proposed.