Inhalant abuse in pregnancy
Inhalant abuse in pregnancy
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DOI：
10.1016/s0889-8545(05)70363-6
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发表时间：
1998-03-01
影响因子：
3.2
通讯作者：
Balster, RL
中科院分区：
文献类型：
--
作者：
Jones, HE;Balster, RL
对怀孕期间滥用吸入剂与对母亲和新生儿的不利健康影响之间的关联的证据进行了审查。大多数证据也来自溶剂滥用者的案例报告，以及一些关于职业暴露于各种滥用溶剂和一氧化二氮的研究。在这些案例报告中，不可能在不考虑产妇保健和产前护理不良以及可能伴随吸入剂滥用生活方式的其他风险因素的情况下，确定特定滥用化学品的直接致畸作用。动物研究的结果为子宫内暴露于广泛滥用的溶剂——甲苯和三氯乙烷（TCE）的不利影响提供了更直接的证据。正确的诊断和治疗在怀孕期间滥用吸入剂应该有助于减少对胎儿的伤害。
Evidence is reviewed of an association between inhalant abuse during pregnancy with adverse health effects on the mother and the newborn. Most evidence comes from case reports in solvent abusers as well, as some studies of occupational exposure to various abused solvents and nitrous oxide. In these case reports, it is not possible to establish a direct teratogenic effect for specific abused chemicals independent of the poor maternal health and prenatal care as well as other risk factors that may have accompanied inhalant abuse lifestyles. Results of animal studies provide more direct evidence for adverse effects of in utero exposure to the widely abused solvents, toluene and trichloroethane (TCE). Proper diagnosis and treatment of inhalant abuse during pregnancy should help minimize harm to the fetus.