Inhibition-related activity in subgenual cingulate is associated with symptom severity in major depression
Inhibition-related activity in subgenual cingulate is associated with symptom severity in major depression
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DOI：
10.1016/j.pscychresns.2008.08.006
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发表时间：
2009-04-30
影响因子：
2.3
通讯作者：
Paulus, Martin
中科院分区：
文献类型：
--
作者：
Matthews, Scott;Simmons, Alan;Paulus, Martin
重度抑郁症（MDD）患者对消极想法的抑制控制能力受损。然而，抑郁症抑制控制受损的大脑机制还没有完全描述。本研究的目的是在一个独特的年轻、健康、未用药的MDD个体人群中检查抑制和错误处理过程中的脑功能。我们假设，MDD受试者在抑制和错误处理过程中，内侧前额叶和前扣带皮层（ACC）的大脑激活会出现临床相关的变化。受试者在功能性磁共振成像（fMRI）过程中执行个性化参数停止信号任务。MDD受试者（n=15）符合当前MDD的DSM-IV标准。健康对照（HC）受试者（n=16）无MDD或其他精神疾病的终生病史。两组在几个社会人口统计变量或行为表现方面没有显着差异。在双侧额下回和左侧膝上前扣带回中，观察到一组通过试验难度相互作用的错误相关激活，这表明MDD中该回路的特定需求失败。此外，还观察到一组试验难度对膝下ACC抑制相关激活的相互作用。在MDD患者中，抑制相关的膝下激活与抑郁症状的严重程度相关，暗示膝下ACC在抑制控制过程中与临床抑郁症相关。出版社：Elsevier爱尔兰Ltd.
Individuals with major depressive disorder (MDD) show impaired inhibitory control over negative thoughts. However, the brain mechanism underlying impaired inhibitory control in MDD has been incompletely described. The objective of this study was to examine brain function during inhibitory and error processing in a unique population of young, healthy, unmedicated MDD individuals. We hypothesized that MDD subjects would show clinically relevant alterations in brain activation in medial prefrontal and anterior cingulate cortex (ACC) during both inhibitory and error processing. Subjects performed an individualized parametric stop-signal task during functional magnetic resonance imaging (fMRI). MDD subjects (n=15) met DSM-IV criteria for current MDD. Healthy control (HC) subjects (n=16) had no lifetime history of MDD or other psychiatric disorder. The groups were not significantly different in several socio-demographic variables or in behavioral performance. A group by trial difficulty interaction on error-related activation in bilateral inferior frontal gyrus and left supragenual ACC was observed, suggesting a demand-specific failure of this circuitry in MDD. Additionally, a group by trial difficulty interaction on inhibition-related activation in subgenual ACC was observed. Among MDD individuals, inhibition-related subgenual activation correlated with depressive symptom severity, implicating subgenual ACC in inhibitory control processes related to clinical depression. Published by Elsevier Ireland Ltd.