Thalamic Neuronal and EMG Activity in Psychogenic Dystonia Compared with Organic Dystonia
Thalamic Neuronal and EMG Activity in Psychogenic Dystonia Compared with Organic Dystonia
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DOI：
10.1002/mds.23565
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发表时间：
2011-06-01
影响因子：
8.6
通讯作者：
Lenz, Frederick A.
中科院分区：
文献类型：
--
作者：
Kobayashi, Kazutaka;Lang, Anthony E.;Lenz, Frederick A.
背景：这是对器质性肌张力障碍受试者和在心因性肌张力障碍诊断前接受丘脑切开术的心因性肌张力障碍受试者之间丘脑神经元和肌电图活动的回顾性分析。结果：肌电图中最低频带（肌张力障碍频率<0.76 Hz）的信噪比因诊断或肌肉的不同而没有显着差异。在器质性肌张力障碍中，腕屈肌 X 二头肌肌电图肌张力障碍频率的一致性显着更高，而任一诊断的相位与零没有明显不同。在丘脑苍白球中继核（腹侧口后部）中，心因性肌张力障碍和器质性肌张力障碍之间的神经元放电率没有明显差异。器质性肌张力障碍中腹侧口腔后部的神经元信噪比显着高于心因性肌张力障碍，而两者均高于患有慢性疼痛的对照组。心因性肌张力障碍和器质性肌张力障碍之间的 Spike X 肌电图一致性显然没有差异。心因性肌张力障碍的小脑中继核（腹侧中间）对关节运动做出反应的丘脑细胞比例高于器质性肌张力障碍。结论：这些结果表明，心因性肌张力障碍和器质性肌张力障碍的一些特征（例如放电率和丘脑重组）相似。其他特征有所不同，例如不同肌肉的肌电图和丘脑神经元信噪比之间的一致性，这可能反映了器质性肌张力障碍的病理生理因素。 (C) 2011 运动障碍学会
Background: This is a retrospective analysis of thalamic neuronal and electromyogram activities between subjects with organic dystonia and a subject with psychogenic dystonia in whom a thalamotomy was carried out before the diagnosis of psychogenic dystonia was made.Results: The signal-to-noise ratio in the lowest frequency band (dystonia frequency < 0.76 Hz) in the electromyogram was not significantly different by diagnosis or muscle. The coherence at dystonia frequency for wrist flexors X biceps electromyograms was significantly higher in organic dystonia, whereas the phase was not apparently different from zero for either diagnosis. In a thalamic pallidal relay nucleus (ventral oral posterior), neuronal firing rates were not apparently different between psychogenic and organic dystonia. The neuronal signal-to-noise ratio in ventral oral posterior was significantly higher in organic dystonia than in psychogenic dystonia, whereas both were greater than in controls with chronic pain. Spike X electromyogram coherence apparently was not different between psychogenic and organic dystonia. The proportion of thalamic cells responding to joint movements was higher in the cerebellar relay nucleus (ventral intermediate) of psychogenic dystonia than in organic dystonia.Conclusions: These results suggest that some features, such as firing rates and thalamic reorganization, are similar in psychogenic and organic dystonia. Other features differ, such as the coherence between the electromyograms from different muscles and the thalamic neuronal signal-to-noise ratio, which may reflect pathophysiological factors in organic dystonia. (C) 2011 Movement Disorder Society