A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population
A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population
复制标题
DOI：
10.1016/j.schres.2007.03.007
复制
发表时间：
2007-07-01
影响因子：
4.5
通讯作者：
He, Lin
中科院分区：
文献类型：
--
作者：
Guo, Sheng-Zhen;Huang, Ke;He, Lin
精神分裂症的突触能功能障碍假说暗示了参与突触能传递的基因是精神分裂症易感性的强有力的候选者。最近的连锁和关联研究已经确定谷氨酸受体，离子型，δ 1基因GRID 1 10 q22作为一个强有力的候选人精神分裂症。在这项关联研究中，我们对来自中国东北的567名中国汉族受试者（260名精神分裂症患者和307名正常对照）的GRID 1基因内的5种遗传变异进行了基因分型。4个SNPs rs 1902666（P = 0.024）、rs 2814351（P = 0.027）、rs 11591408（P = 0.0000107）和rs 999383（P = 0.000093）与精神分裂症显著相关。单倍型分析也显示了显著性，SNPs 1-2和SNPs 3-4-5单倍型的总体P值分别为0.0081和0.00076。我们的研究结果强烈支持先前报道的关联研究，暗示GRID 1在精神分裂症的病因。(c)2007 Elsevier B. V.保留所有权利。
The glutamatergic dysfunction hypothesis of schizophrenia implicates the genes involved in glutamatergic transmission as strong candidates for schizophrenia-susceptibility. Recent linkage and association studies have identified the glutamate receptor, ionotropic, delta 1 gene GRID1 on 10q22 as a strong candidate for schizophrenia. In this current association study, we genotyped five genetic variants within the GRID1 gene in 567 Chinese Han subjects recruited from Northeast of China (260 schizophrenics and 307 normal controls). Four SNPs, rs1902666 (P = 0.024), rs2814351 (P = 0.027), rs11591408 (P = 0.0000107) and rs999383 (P = 0.000093) were found to be significantly associated with schizophrenia. Haplotype analysis also revealed significance with global P values of 0.0081 and 0.00076 for SNPs 1-2 and SNPs 3-4-5 haplotypes, respectively. Our results strongly support previously reported association studies, implicating GRID1 in the etiology of schizophrenia. (c) 2007 Elsevier B.V. All rights reserved.