Very long term studies of the seeding of beta-amyloidosis in primates.
Very long term studies of the seeding of beta-amyloidosis in primates.
复制标题
关于灵长类动物 β-淀粉样变性传播的超长期研究。
DOI：
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发表时间：
2006
影响因子：
3.3
通讯作者：
R. Cummings
中科院分区：
文献类型：
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作者：
R. Ridley;H. Baker;C. Windle;R. Cummings
在1-8年前脑内注射含有β-淀粉样蛋白的人或绒猴脑匀浆的16/18只年龄<10岁的绒猴和8/9只年龄>10岁的绒猴中发现脑β-淀粉样变性。在注射了合成A β肽、CSF或不含β淀粉样蛋白的脑组织的12只<10岁的绒猴中仅发现2只，15只>10岁的绒猴中仅发现1只。脑β-淀粉样变性见于0/11只年龄<10岁的未注射的绒猴和5/29只年龄>10岁的未注射的绒猴。β-淀粉样变性包括小血管和大血管血管病变和一些遍布皮质的斑块，在注射的绒猴和未注射的绒猴中，当存在时，在性质上相似。在那些注射的阳性绒猴中，β-淀粉样变性的量与年龄或潜伏期无关，但3只注射的无β-淀粉样变性的绒猴的潜伏期<3.5年。我们的结论是β-淀粉样蛋白，或相关因素，可以启动或加速灵长类动物脑淀粉样变性的过程。
Cerebral beta-amyloidosis was found in 16/18 marmosets aged <10 yrs and 8/9 marmosets aged >10 yrs, injected intracerebrally with human or marmoset brain homogenate containing beta-amyloid 1-8 years previously. It was found in only 2/12 marmosets aged <10 yrs and 1/15 marmosets aged >10 yrs, injected with synthetic Abeta-peptides, CSF, or brain tissue which did not contain beta-amyloid. Cerebral beta-amyloidosis was found in 0/11 uninjected marmosets aged <10 yrs and in 5/29 uninjected marmosets aged >10 yrs. The beta-amyloidosis comprised small and large vessel angiopathy and some plaques throughout cortex and was qualitatively similar in injected marmosets and, when present, in uninjected marmosets. Of those injected marmosets which were positive, the amount of beta-amyloidosis was unrelated to age or incubation times but the 3 injected marmosets without beta-amyloidosis had incubation times of <3.5 years. We conclude that beta-amyloid, or associated factors, can initiate or accelerate the process of cerebral amyloidosis in primates.