Chemokines and chemokine receptors: their manifold roles in homeostasis and disease.
Chemokines and chemokine receptors: their manifold roles in homeostasis and disease.
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DOI：
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发表时间：
2004-04
影响因子：
24.1
通讯作者：
Y. Le;Ye Zhou;P. Iribarren;Jiming Wang
中科院分区：
文献类型：
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作者：
Y. Le;Ye Zhou;P. Iribarren;Jiming Wang
趋化因子是一个小蛋白超家族，与靶细胞上的G蛋白偶联受体结合，最初被发现是免疫细胞定向迁移到炎症和损伤部位的媒介。近年来，趋化因子的功能已明显超出了白细胞趋化的范围。它们参与器官发育、血管生成/血管稳定、白细胞运输和归巢、肿瘤发生和转移，以及对微生物感染的免疫反应。因此，趋化因子及其受体是调节宿主在病理生理条件下的反应以及对人类疾病进行治疗干预的重要靶点。
Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells and were originally discovered as mediators of directional migration of immune cells to sites of inflammation and injury. In recent years, it has become clear that the function of chemokines extends well beyond the role in leukocyte chemotaxis. They participate in organ development, angiogenesis/angiostasis, leukocyte trafficking and homing, tumorigenesis and metastasis, as well as in immune responses to microbial infection. Therefore, chemokines and their receptors are important targets for modulation of host responses in pathophysiological conditions and for therapeutic intervention of human diseases.