Electrically evoked basilar membrane motion.
Electrically evoked basilar membrane motion.
复制标题
电诱发基底膜运动。
DOI：
--
复制
发表时间：
1995
影响因子：
2.4
通讯作者：
A. Hubbard
中科院分区：
文献类型：
--
作者：
S. Xue;D. Mountain;A. Hubbard
许多研究人员在分离的 OHC 制剂中证明了电诱导的外毛细胞 (OHC) 运动，它被认为是活跃过程中的关键机制，它带来了哺乳动物耳蜗优异的灵敏度和频率选择性。在这项研究中，通过直接测量注入阶介质的正弦电流引起的基底膜运动，在体内证明了沙鼠耳蜗中的电-机械转导。根据基底膜 (BM) 对声刺激的响应确定，测量位置的特征频率 (CF) 约为 40 kHz。结果表明，频率低于 10 Hz 至超过 40 kHz 的电流可引起基底膜运动。 BM 速度对恒定电流刺激（从 100 Hz 到 10,000 Hz）响应的幅度和相位与恒定 umbo 速度的声驱动 BM 速度相似。对于该范围内的频率，50 微安电流引起的 BM 运动与 60 dB SPL 声刺激引起的 BM 运动相当。电诱发的 BM 运动的相位表明，注入阶介质的正电流导致 BM 向前庭阶移动，频率在 100 至 10 kHz 之间。该结果与电诱发的 BM 运动是由于电诱发的 OHC 长度变化引起的假设一致。
Electrically induced outer hair cell (OHC) motility, demonstrated by a number of investigators in isolated OHC preparations, has been considered to be a key mechanism in the active process which brings about the excellent sensitivity and frequency selectivity of the mammalian cochlea. In this study, electrical-to-mechanical transduction in the gerbil cochlea was demonstrated in vivo by direct measurement of basilar membrane motion evoked by sinusoidal electrical current injected into the scala media. The characteristic frequency (CF) of the measurement place was approximately 40 kHz as determined by the basilar membrane (BM) responses to acoustic stimulation. The results showed that basilar membrane motion could be evoked by electrical current of frequencies from below 10 Hz to exceeding 40 kHz. The magnitude and phase of the BM velocity response to constant current stimulation, from 100 Hz to 10,000 Hz, were similar to the acoustically driven BM velocity for constant umbo velocity. For frequencies in this range, the BM motion evoked by a current of 50 microA was comparable to the BM motion evoked by a 60 dB SPL acoustic stimulus. The phase of the electrically evoked BM motion indicates that positive current injected into the scala media caused the BM to move toward scala vestibuli for frequencies between 100 and 10 kHz. This result is consistent with the hypothesis that the electrically evoked BM motion is due to electrically evoked OHC length changes.